(12) Oversettelse av europeisk patentskrift (11) NO/EP 2285808 B1 (19) NO NORGE (51) Int Cl. C07D 471/20 (2006.01) A61K 31/407 (2006.01) A61K 31/424 (2006.01) A61K 31/437 (2006.01) A61K 31/438 (2006.01) A61K 31/55 (2006.01) A61P 33/02 (2006.01) A61P 33/06 (2006.01) C07D 487/20 (2006.01) C07D 498/22 (2006.01) Patentstyret (21) Oversettelse publisert 2014.04.07 (80) Dato for Den Europeiske Patentmyndighets publisering av det meddelte patentet 2013.11.20 (86) Europeisk søknadsnr 09737965.5 (86) Europeisk innleveringsdag 2009.04.01 (87) Den europeiske søknadens Publiseringsdato 2011.02.23 (30) Prioritet 2008.04.29, EP, 08155342 2009.01.22, EP, 09151117 (84) Utpekte stater AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR (73) Innehaver Novartis AG, Lichtstrasse 35, 4056 Basel, Sveits (72) Oppfinner ANG, Shi Hua, Novartis Institute for Tropical Diseases Pte Ltd10 Biopolis Road05-01 Chromos, Singapore 138670, Singapore KRASTEL, Philipp, Novartis Pharma AGPostfach, CH-4002 Basel, Sveits LEONG, Seh Yong, Novartis Institute for Tropical Diseases Pte Ltd10 Biopolis Road05-01 Chromos, Singapore 138670, Singapore TAN, Liying Jocelyn, Novartis Institute for Tropical Diseases Pte Ltd10 Biopolis Road05-01 Chromos, Singapore 138670, Singapore WONG, Wei Lin Josephine, Novartis Institute for Tropical Diseases Pte Ltd10 Biopolis Road05-01 Chromos, Singapore 138670, Singapore YEUNG, Bryan KS, Novartis Institute for Tropical Diseases Pte Ltd10 Biopolis Road05-01 Chromos, Singapore 138670, Singapore ZOU, Bin, Novartis Institute for Tropical Diseases Pte Ltd10 Biopolis Road05-01 Chromos, Singapore 138670, Singapore (74) Fullmektig Zacco Norway AS, Postboks 2003 Vika, 0125 OSLO, Norge (54) Benevnelse Spiroindolderivater for behandling av parasittiske sykdommer (56) Anførte publikasjoner EP-A- 0 466 548, WO-A-2005/009370 BREMNER JOHN B ET AL: "A compact approach to an isomeric iheyamine a system and x-ray crystal structure of 5-methyl-5H-azepino[2,3-b:4,5-b']diindole" SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS GROUP, PHILADELPHIA, PA, vol. 38, no. 12, 1 January 2008 (2008-01-01), pages 1931-1939, XP009115559 ISSN: 0039-7911 [retrieved on 2008-01-01] CHIYANZU IDAN ET AL: "Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives" BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 13, no. 9, 1 January 2005 (2005-01-01), pages 3249-3261, XP002482130 ISSN: 0968-0896 GRIGORYAN N P ET AL: "Synthesis and antispasmodic activity of spiro[.beta.-carbolineindolo nes] and spiro[indoleindolo[2,3-c]azepinones]", HAYASTANI KIMIAKAN HANDES, IZDATEL'STVO GITUTYN NAN RESPUBLIKI ARMENII, vol. 58, no. 3, 1 January 2005 (2005-01-01), pages 100-104, XP009102457, ISSN: 1561-4190 HUDSON, A.T.: "Patent focus on antiparasitic agents" EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 10, no. 2, 1 January 2000 (2000-01-01), pages 153-163, XP002527893