(12) Oversettelse av europeisk patentskrift

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1 (12) Oversettelse av europeisk patentskrift (11) NO/EP B1 (19) NO NORGE (51) Int Cl. C12N 9/50 ( ) C07K 14/415 ( ) C12N 15/29 ( ) C12N 15/57 ( ) C12N 15/81 ( ) A23J 3/34 ( ) A61K 38/48 ( ) A61Q 19/00 ( ) Patentstyret (21) Oversettelse publisert (80) Dato for Den Europeiske Patentmyndighets publisering av det meddelte patentet (86) Europeisk søknadsnr (86) Europeisk innleveringsdag (87) Den europeiske søknadens Publiseringsdato (30) Prioritet , EP, (84) Utpekte stater AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (73) Innehaver URSAPHARM Arzneimittel GmbH, Postfach , Saarbrücken, Tyskland (72) Oppfinner MÜLLER, Rolf, Kirkelerstrasse 114, Blieskastel, Tyskland LUNIAK, Nora, Beim Weisen Stein 8, Saarbrücken, Tyskland ESCHMANN, Klaus, Lothringer Strasse 26, Kleinblittersdorf, Tyskland (74) Fullmektig Zacco Norway AS, Postboks 2003 Vika, 0125 OSLO, Norge (54) Benevnelse Rekombinant fremstilling av utvalgte bromelainfraksjoner (56) Anførte publikasjoner WO-A-00/03729, WO-A-00/14253, WO-A-2005/ CARTER CAROL E ET AL: "Mutagenesis and kinetic studies of a plant cysteine proteinase with an unusual arrangement of acidic amino acids in and around the active site" BIOCHEMISTRY, vol. 39, no. 36, 12 September 2000 ( ), pages , XP ISSN: CREGG J M ET AL: "RECOMBINANT PROTEIN EXPRESSION IN PICHIA PASTORIS" MOLECULAR BIOTECHNOLOGY, TOTOWA, NJ, US, vol. 16, no. 1, September 2000 ( ), pages 23-52, XP ISSN: DATABASE EMBL [Online] 14 November 1997 ( ), "Ananas comosus mrna for ananain precursor, complete cds" XP retrieved from EBI accession no. EMBL:ACAJ2477 Database accession no. AJ cited in the application DATABASE UniProt [Online] 1 January 1998 ( ), "FBSB precursor." XP retrieved from EBI accession no. UNIPROT:O23799 Database accession no. O23799 DATABASE UniProt [Online] 1 January 1998 ( ), "Fruit bromelain precursor (EC ) (Allergen Ana c 2)." XP retrieved from EBI accession no. UNIPROT:O23791 Database accession no. O23791 LUNIAK N: "Heterologe Expression von Proteinen aus Ananas comosus zur Aufklärung der pharmakologischen Wirkmechanismen von Bromelain" 30 October 2007 ( ), UNIVERSITÄT DES SAARLANDES, SAARBRÜCKEN, XP the whole document MAURER H R: "Bromelain: biochemistry, pharmacology and medical use" CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, HEIDELBERG, DE, vol. 58, no. 9, August 2001 ( ), pages , XP ISSN: X PAWAN GUPTA ET AL: "Bioaffinity Based Oriented Immobilization of Stem Bromelain" BIOTECHNOLOGY LETTERS, KLUWER ACADEMIC PUBLISHERS, DO, vol. 28, no. 12, 8 June 2006 ( ), pages , XP ISSN:

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