C rhinovirus picornain 3C A HIV-1 retropepsin A feline immunodeficiency virus retropepsin

Transkript

1 Peptide Sequence Annotation AADHDG CAS-L1 AAEAISDA AAEHDG CAS-L2 AAEYGAEA AAGAMFLE M stromelysin 3 (MMP-11) AAQNASMW A nodavirus endopeptidase AASGFASP M vibriolysin ADAHDG CAS-L3 ADAPKGGG M angiotensin-converting enzyme 2 ADATDG CAS-L5 ADAVMDNP ADDPDG CAS-21 ADEPDG CAS-L11 ADETDG CAS-22 ADEVDG CAS-23 ADGKKPSS S plasmin AEALERMF AEEQGVTD C rhinovirus picornain 3C AETFYVDG AETWYIDG A feline immunodeficiency virus retropepsin AFAHDG CAS-L24 AFATDG CAS-25 AFDHDG CAS-L26 AFDTDG CAS-27 AFEHDG CAS-28 AFETDG CAS-29 AFGHDG CAS-30 AFGTDG CAS-31 AFQHDG CAS-32 AFQTDG CAS-33 AFSHDG CAS-L34 AFSTDG CAS-35 AFTHDG CAS-L36 AGERGFFY AGLQRGGG M carboxypeptidase N AGSHLVEA AIDIDG CAS-L37 AIDPDG CAS-38 AIDTDG CAS-39 AIDVDG CAS-L40 AIEHDG CAS-L41 AIEIDG CAS-L42 AIENDG CAS-43 AIEPDG CAS-44 AIEQDG CAS-45 AIESDG CAS-46 AIETDG CAS-47 AIEVDG CAS-48 AIFQGPID C rhinovirus picornain 3C

2 AIGHDG CAS-49 AIGNDG CAS-L50 AIGPDG CAS-L51 AIGQDG CAS-52 AIGSDG CAS-53 AIGTDG CAS-54 AIPMSIPP M serralysin AISHDG CAS-L55 AISNDG CAS-L56 AISPDG CAS-57 AISQDG CAS-58 AISSDG CAS-59 AISTDG CAS-L60 AKQRAKRD S furin AKRQGLPV C rhinovirus picornain 3C AKRRAKRD S furin AKRRTKRD S furin ALAALAKK M gametolysin ALDIDG CAS-L61 ALDPDG CAS-62 ALDTDG CAS-63 ALDVDG CAS-L64 ALEIDG CAS-L65 ALEPDG CAS-L66 ALETDG CAS-67 ALEVDG CAS-68 ALFQGPLQ C poliovirus-type picornain 3C ALGAQMGA ALYLVEGE AMEQGITN C poliovirus-type picornain 3C ANLGRPAL C foot-and-mouth disease virus L-proteinase ANVSTVLT APDIDG CAS-69 APDPDG CAS-70 APDTDG CAS-L71 APDVDG CAS-72 APEIDG CAS-73 APEPDG CAS-L74 APETDG CAS-75 APEVDG CAS-76 APHMALVP S endopeptidase Clp (type 1) APPPVVLL APRELKEQ M stromelysin 1 APRSSMSN M vibriolysin APSWLLTA M gelatinase A AQDFVQWL S chymotrypsin A (cattle-type) AQKGFTLI A type IV prepilin peptidase 1 AQRRAEEE S proprotein convertase 2 ARSVVRDV M leishmanolysin ARVLGEAL A HIV-2 retropepsin

3 ARVYGEAL ARVYIHPF ASILPVIL ATDNFAAA ATIMMQRG ATTANYDD ATVLTVAL AVDASGDP AVDIDG AVDPDG AVDTDG AVDVDG AVEIDG AVEPDG AVETDG AVEVDG AVKKYLNS AVLKVLTT AVRSSSRG AVRWLLTA AVSWLLTA AVVGGPGP AWAHDG AWATDG AWDHDG AWDTDG AWEHDG AWETDG AWGHDG AWGTDG AWQHDG AWQTDG AWSHDG AWSTDG AWTHDG AWTTDG AWVHDG AWVTDG AYAHDG AYATDG AYDHDG AYDTDG AYEHDG AYETDG AYGHDG AYGTDG AYQHDG AYQTDG AYSDMREA AYSHDG A aspergillopepsin I A retropepsin (human T-cell leukemia virus) A tetravirus endopeptidase S neutrophil elastase A Rous sarcoma virus retropepsin S cytomegalovirus assemblin CAS-L77 CAS-78 CAS-79 CAS-80 CAS-81 CAS-82 CAS-83 CAS-L84 S tryptase alpha C gingipain K M ADAM9 endopeptidase M gelatinase A (MMP-2) M gelatinase A (MMP-2) C cruzipain CAS-L85 CAS-L86 CAS-L87 CAS-88 CAS-89 CAS-L90 CAS-91 CAS-92 CAS-L93 CAS-94 CAS-95 CAS-96 CAS-97 CAS-L98 CAS-L99 CAS-L100 CAS-101 CAS-102 CAS-103 CAS-104 CAS-105 CAS-106 CAS-107 CAS-108 CAS-109 CAS-110 CAS-111

4 AYSTDG CAS-112 AYTHDG CAS-113 AYTTDG CAS-114 AYVHDG CAS-115 AYVTDG CAS-116 CGERGFFY CGSHLVEA DDDKGGGG S enteropeptidase DDDKIVGG A penicillopepsin DEEDILSH C caspase-3 DEVDGGGG C caspase-3 DEVDGVDE C caspase-3 DEVDNKVK C caspase-3 DFTRVVGG S coagulation factor XIa DFVQWLMN S thermomycolin DGPDGPEE C caspase-3 DHLSDTST M PHEX endopeptidase DIGAALVE C sindbis virus-type nsp2 proteinase DIIWINTP M endothelin-converting enzyme 1 DIIWVNTP M endothelin-converting enzyme 1 DKTHTCPP C cathepsin L-like endopeptidase (Fasciola sp.) DLERAASG A yapsin 1 DLGRFQTF M stromelysin 1 DRVYIHPF A aspergillopepsin I DSGGFMLT DSRRAQDF A phytepsin DSVDAKPD C caspase-7 DTDLYDYY S cathepsin G DTKKAVKY M bontoxilysin DTLEVMRK DVAEYSLF DVANYNFF M gelatinase A DVAQFVLT DVEAATSL S cytomegalovirus assemblin DVGHFRTF DVVSLKGL DYMGWMDF M neprilysin EAAEARRG M ADAMTS4 endopeptidase EAGRNAQV C separase EAIPMSIP M collagenase 1 (MMP-1) EALPMSIP EALYLVAG EALYLVCG EALYLVEG M thermolysin EDKRHSQG S proprotein convertase 2 EERARAKW C calpain-1 EFERHAEG S proprotein convertase 1 EFKRELEG S proprotein convertase 2 EFVFGALK A plasmepsin 2 EGERGFFY C gingipain R

5 EGKRSYSM S proprotein convertase 1 EGRRGAAE S flavivirin EGSHLVEA M thermolysin EGSHLVEA M atrolysin A EGVFYTDG A spumapepsin EKQRIIGG S complement component activated C1r ELGRGGGG S coagulation factor IXa EMARRPPG S kallikrein mk1 (Mus musculus) ENPRKYVM S proprotein convertase 2 EPGRYTPV C gingipain R EPTTIIRQ EQGRRLGE C separase ERDQKLSE M bontoxilysin ERGFFYTP A pepsin A ERGFFYTP ERGFFYTP ERGFFYTP S cathepsin G ERGRKRAH C separase ERMFLSFP ESDVMGRG M atrolysin E ESENGLEE C legumain (plant beta form) ESQSLTLT M collagenase cola ESSNLFVL M membrane-type matrix metalloproteinase 1 ETRNGVEE C legumain (plant beta form) ETSAAKLK M bontoxilysin EVGRDAPA C separase EVGRRFSP C separase EVHHQKLV M ADAM9 endopeptidase EVKMDAEF A memapsin-2 EVVGAPAA C cruzipain EVVTSTWV S hepacivirin FATEFASE FESFGDLS FFTEGGHD A saccharopepsin FGLMGGGG C calpain-1 FGRRSIPV S flavivirin FGTEFASE FGTEFGSE FHKRQHPG S proprotein convertase 1 FHLLVYSG A aspergillopepsin I FHLQGPED C calicivirin FKLEVAQE FKNEVAAE FKNEVANE FKNEVARE FKQTMSTM S subtilisin BPN' FLADLDTT M stromelysin 1 FLKRFAEA S proprotein convertase 1 FLQSLKGF M stromelysin 1 FLSFPTTK

6 FLVSYVKN M sporulation factor SpoIVFB FMKKDAEE S proprotein convertase 1 FMMNDEEA M procollagen C-proteinase FNPRTFGS S coagulation factor Xa C murine hepatitis coronavirus papain-like FPSAGKKV endopeptidase 1 FQAYPLRE A Rous sarcoma virus retropepsin FRRRHADG S proprotein convertase 1 FSARGHRP FSFLGEAF M stromelysin 1 FSPFRGGG M carboxypeptidase N FTASLKSN M fragilysin FTKLISGG S streptogrisin B FTKRSSLT S kallikrein mk13 (Mus musculus) FVNQHLAG FVNQHLCG FVNQHLEG S subtilisin Carlsberg FVQWLMNT S chymotrypsin A (cattle-type) FWHRGVTK S furin FWKTFTSS C calpain-1 GAAKAAAG A rhizopuspepsin GADVVDG C caspase 3 GAIEGRGA S coagulation factor Xa GAKRGGGG S tryptase beta 1 (Homo sapiens) GALALRVT M collagenase 1 (MMP-1) GAMFLEAI M collagenase 1 (MMP-1) GANQRATG M bontoxilysin GARDMWRA GARRSGDV S flavivirin GASQFESS M IgA1-specific metalloendopeptidase GASQFETS M IgA1-specific metalloendopeptidase GAVDVAD Caspase-2 GAVHLPQP M ADAM9 endopeptidase GAVLKVLT GAYVADG Caspase-1 GDDDDKAG S enterokinase GDEVDGA Caspase-3 GDKELRTG M matrilysin-2 (MMP-26) GDRVYIHP A pepsin A GEARGGGG S coagulation factor XIa GELEGRGT M ADAMTS4 endopeptidase GELYENKP C calpain-1 GENLYFQG C tobacco etch virus protease GEPGLVGY M atrolysin E GEPRGGGG S coagulation factor XIa GERGFFYT M thermolysin GFALADAS M flavastacin GFFYTPKA GFFYTPKA GFFYTPKA S chymotrypsin A (cattle-type)

7 GFHLLVEA M stromelysin 2 GFLRRIRP C calpain-1 GFSAFKGG M endothelin-converting enzyme 1 GFSPFGGG M angiotensin-converting enzyme 2 GFSPFRGG M endothelin-converting enzyme 1 GFVNQHLE M atrolysin A GGAAFAGG M pseudolysin GGAGGLAG M aeruginolysin GGAGLAGG M thermolysin GGAPKGGG M angiotensin-converting enzyme 2 GGELYENK M endothelin-converting enzyme 1 GGFARGGG M carboxypeptidase E GGFFVVHG A gastricsin GGFLRGGG M carboxypeptidase M GGFMKGGG M carboxypeptidase M GGFPGPIG S X-Pro dipeptidyl-peptidase GGGPRGGG C gingipain R GGGSVIMG M carboxypeptidase E GGGVLSAA GGKMKVNG M pappalysin-1 GGKRDAEN S proprotein convertase 2 GGKRGGGG S complement factor B GGLWMGGG C cathepsin X GGPGGPAG M oligopeptidase A GGSSDAAE M PHEX endopeptidase GGVLSGGG C cathepsin X GGVRGPRL S Ancrod GGVRGPRV GGWRGGGG S coagulation factor IXa GGYARGGG M carboxypeptidase E GGYPFPGP S X-Pro dipeptidyl-peptidase GHARLVHG M atrolysin A GHARLVHV M atrolysin C GIEFGRLG GILTLKYP M fragilysin GIQAIYGP M collagenase 1 GIQFTESS GITCSGRQ S lon protease GKIGGLIG S proteinase K GKKRRPVK S proprotein convertase 2 GKPNMIDA M matrilysin-2 (MMP-26) GLAHAEAG M pseudolysin GLALALEP A memapsin-1 GLARSNLD S complement factor B GLEHDGA Caspase-8 GLGNVYYY GLKRSPQL S proprotein convertase 1 GLQRALEI S complement component activated C1s GLVPRGSG GLWMRFAG M gametolysin

8 GLWMRGGG C cathepsin X GNFKSQLQ GNQRATKG M bontoxilysin GPEGLRVG M collagenase 1 (MMP-1) GPFRGGGG S kallikrein hk1 GPGGVHAK M matrilysin-2 (MMP-26) GPGGVWAA GPIGFEGE M stromelysin 1 GPLALWAR M collagenase 1 (MMP-1) GPLAVKAR M matrilysin-2 (MMP-26) GPLAYWAR M matrilysin-2 GPLELRAG M matrilysin (MMP-7) GPLGIAGR M matrilysin (MMP-7) GPLGIAGR M matrilysin (MMP-7) GPLGLGAR GPLGLKAR M collagenase 2 (MMP-8) GPLGLKAR M collagenase 2 (MMP-8) GPLGLWAR M collagenase 2 GPMPFGGG M angiotensin-converting enzyme 2 GPPGLKGL GPQAIAGQ M matrilysin (MMP-7) GPQGIAGQ M collagenase 1 (MMP-1) GPQGIFGQ M gelatinase B (MMP-9) GPQGIQGG M collagenase 2 (MMP-8) GPQGIWGQ M collagenase 2 (MMP-8) GPSFRAPD S chymotrypsin A (cattle-type) GQEGMTLL A type IV prepilin peptidase 1 GQPDALNV M stromelysin 1 GQRRGGGG S plasma kallikrein GRASLNHG GRGHARLV M atrolysin A GRGIIAGG S coagulation factor C (horse-shoe crab) activated GRGRGGGG S coagulation factor IXa GRLLVVYP GRRASVAG S tripeptidyl-peptidase II GRRDDSSE M PHEX endopeptidase GRTFGSFP A plasmepsin 2 GRVYIHPF S tripeptidyl-peptidase I GSAESMGP C endopeptidase 1 (mite) GSARAGDG C gingipain R GSHLVEAL A pepsin A GSLPQKSQ M ADAM10 endopeptidase GSLRRSSC M nardilysin GTRLSESS GVGAAPSY C sindbis virus-type nsp2 proteinase GVHLTPEE GVLRGGGG S kallikrein hk1 GVLSEGGG C cathepsin X GVPRGGGG GVPRSFRG

9 GWAGGNAS M beta-lytic metalloendopeptidase (myxobacteria) GYGGFLGG M thermolysin GYGGFMGG M peptidyl-dipeptidase Acer GYMGWMDG M beta-lytic metalloendopeptidase (myxobacteria) C murine hepatitis coronavirus papain-like GYRGVKPI endopeptidase 1 HHQKLVFF M ADAM10 endopeptidase HLGGAKQA HLIAAVKA A spumapepsin HLSFMAIP A chymosin HLVEALYL HMLGLPST M anthrax lethal factor HPFHLGGG M angiotensin-converting enzyme 2 HPVELLAR HQSGFSMI A type IV prepilin peptidase 1 HRGRTLEI S complement factor I HTEKLVTS M matrilysin-2 (MMP-26) HTVEKGGK M peptidyl-Lys metalloendopeptidase HWENQVGH A spumapepsin IAGRSLNP M stromelysin 1 IAKRHDEF S proprotein convertase 1 IDGRIVEG S coagulation factor Xa IEGRGGGG S coagulation factor Xa IEGRIVEG S coagulation factor Xa IEGRTSED S coagulation factor Xa IEPRSFSQ IEPRSFSQ S protein C (activated) IESQRIMK C hepatitis A virus-type picornain 3C IFAGIKKK M leishmanolysin IGANVSIG S proteinase K IGGLIGAN S proteinase K IHPFHLLV S S nerve growth factor gamma subunit (Mus sp.) IHPFHLVI S tonin IKKRQQGG C gingipain R IKPRIVGG S coagulation factor XIIa IKVTGKKS S SpoIVB peptidase ILPTELIE A Moloney murine leukemia virus-type retropepsin IMAENRKS IPENFFGV IPENFFGV M atrolysin C IQADSGPI C caspase-6 IQIRSVAK IQSRIVGG S kallikrein hk2 (Homo sapiens) IRKRANSF M russellysin ISLMKRPP C cruzipain ISLMKRPP S kallikrein hk1 ISQLSPCH S lon protease ISVDRPVK C calpain-3 ITTAGPSD C rhinovirus picornain 2A ITVQTVTW M membrane-type matrix metalloproteinase 1 IVGLGVQS C adenain

10 IYFRMKAP A omptin IYLQSDSE C tobacco etch virus NIa protease IYTQSLDD C tobacco etch virus NIa protease KAAYWASQ A human endogenous retrovirus K retropepsin KAKRAASQ S kexin KALAALAK M gametolysin KALHVTNI M stromelysin 3 (MMP-11) KALKLNFA M anthrax lethal factor KDIFPVTE A Mason-Pfizer leukemia virus retropepsin KDKRYGGF S proprotein convertase 2 KDLRISCM M anthrax lethal factor KEEEGLGS M ADAMTS4 endopeptidase KGDTANNP C calpain-1 KGTFATLS KGYRSQRG S plasmin KHERDQGH S tryptase alpha KIIEGRLG KKKRKVGG S granzyme K KKSGCLVL C Ulp1 endopeptidase KKTRNLKK S protein C (activated) KKYLNSIL M pitrilysin KLDKSFSK M ADAM17 endopeptidase KLTRAEAV S coagulation factor XIa KLVFFAED A memapsin-1 KMQLLAEL KPAPSPAA S IgA1-specific serine endopeptidase (Neisseria sp.) KPEGIDSR M matrilysin-2 (MMP-26) KPQQFFGL M coccolysin KPQQFFGL KPRALTAG M gelatinase A KPTPIQLN M anthrax lethal factor KPVEVWRK KQAYGAVS A Mason-Pfizer leukemia virus retropepsin KTNSVIAN KTRREAED A yapsin 1 KVDMVQYT KVFMSKPE C tobacco etch virus NIa protease KVTAGSPI S repressor LexA KYNTSAIS C nuclear-inclusion-a endopeptidase (plum pox virus) LAKKGGEA S flavivirin LAQAVRSS M ADAM10 endopeptidase LAQFVRSS M ADAM17 endopeptidase LAQNVRSS M ADAM17 endopeptidase LAYFYPEL A phytepsin LAYGLRSK LDKFLASV LDKREAEA A yapsin 2 LDRRGIQR S protein C (activated) LECLLSIP A bovine leukemia virus retropepsin LEGSHLVE S neutrophil elastase

11 LERMFLSF LESDYFGK C caspase-1 LEVLFQGP HRV 3C Protease LFEKKVYL S plasmin LFKRLPVP S kexin LFSQAKIS C hepatitis A virus-type picornain 3C LFYSFWER M leishmanolysin LGEFLRTH A gastricsin LGEFVSET LGIRSFRN LGLARGGG M carboxypeptidase N LGPVTPEI S neutrophil elastase LGRLLVVY LGRRHADG S proprotein convertase 1 LIAYLKKA M leishmanolysin LIAYSKKA M leishmanolysin LIGANVSI S proteinase K LISWIKRK LKELAVGD S pestivirus NS3 polyprotein peptidase LKNRVVAG A omptin LLAGCSSN A signal peptidase II LLLQGFIQ C calpain-1 LLNVGSRR C rhinovirus picornain 2A LLRFFVAP A chymosin LLSALVET M collagenase 1 LLVTLAAH LLVTLASH LLVYGGGG C cathepsin B LNAGFTAS M stromelysin 1 LNGATPSA C tymovirus endopeptidase LNGAYKAI LNGGAAGG C tymovirus endopeptidase LNGGAFNW C adenain LPALISWI LPLPAQQP M enamelysin LPSRSSKI S complement factor I LPVENRLY LQKGFTLI A type IV prepilin peptidase 1 LQKRGIVE S proprotein convertase 1 LQLDCVAV C caspase-8 LQQLGQQS S lon protease LQVLTLNI A Moloney murine leukemia virus-type retropepsin LQVLTLNL A Moloney murine leukemia virus-type retropepsin LRAYLLLP M stromelysin 1 LRGGKQLE C ubiquitin-specific protease 5 LRGGMQIF C ubiquitin-specific protease 5 LRLAITAG M gelatinase A (MMP-2) LRPRFKII LRTNDVKE C legumain (chordate) LRTNNMKE C legumain (chordate)

12 LRTQSFSG C hepatitis A virus-type picornain 3C LRTQSFSN C hepatitis A virus-type picornain 3C LRVNKIKD A saccharopepsin LSGLSRIV S chymotrypsin A (cattle-type) LSPRTFHP LSTQMMRN C hepatitis A virus-type picornain 3C LSTRGPPR C rhinovirus picornain 2A LSVNAQTS S SpoIVB peptidase LTFLCLSF M S2P protease LTGGMRRA C adenain LTGNGRFR C adenain LTQENQDR S glutamyl endopeptidase I LTQSKFVG M pappalysin-1 LTRYTNAN S chymotrypsin A (cattle-type) LTTYGFGH C poliovirus-type picornain 2A LVAGERGF LVCGERGF LVEALYLV LVEALYLV LVEALYLV LVEGERGF A penicillopepsin LVFFAEDV A memapsin-1 LVNASSAA S assemblin LVQASASG S cytomegalovirus assemblin LVQCGFPS S UmuD protein LVTLAAHL LWMRFGGG C cathepsin X LWSQGISD C hepatitis A virus-type picornain 3C LYENKPRR C legumain (chordate) LYFQSGTV C tobacco etch virus NIa protease LYKRYGGF S proprotein convertase 1 LYLVAGER LYLVCGER LYLVEGER S neutrophil elastase LYPEEILD C cathepsin K MAASLKRP MATRKMHD S protein C (activated) MAVKKYLN S tryptase alpha MEKRYGGF S proprotein convertase 2 MFLEAIPM S glutamyl endopeptidase I MGRGHARL M atrolysin E MGWMDEID M meprin beta subunit MHKALTAG M gelatinase A MHLQGPED C calicivirin MIEFSESS MKGGVLPF C adenain MKLEIASE MKYEIAQE MKYEIASE MNTNDLEE C legumain (chordate)

13 MQLGRGGG M carboxypeptidase N MQLLAELT MRGGILPL C adenain MSGGAFSW C adenain MSTMSAAK S subtilisin BPN' MTPRSEGS MYKREADA S kexin MYKREAEA S kexin MYKREANA S kexin NAYKKGEG C gingipain K NDTDANPR C caspase-6 NFAAQYDP M procollagen I N-endopeptidase NFAPQLSY M procollagen I N-endopeptidase NGAKPQSV C gingipain K NGKRADFT C gingipain K NISDLTAG M gelatinase A (MMP-2) NISHKDMQ S C5a peptidase NITYRGTG C calpain-1 NKPRRPYI M thimet oligopeptidase NLAGILKE M membrane-type matrix metalloproteinase 1 NLDMIQFT NLDMTRLS NLERSVDS A yapsin 1 NLTRIVGG S coagulation factor IXa NLVYMVTG M ADAMTS13 endopeptidase NPLYKEAT C calpain-1 NPRGIVTD NQDRGTHV C clostripain NQHLAGSH NQHLCGSH NQHLEGSH S cathepsin G NQKRYGGF S proprotein convertase 2 NRTASLTD M tentoxilysin NSNRAFGV C gingipain R NTKRNRNN S proprotein convertase 2 PAEFGRLG A pepsin A PAILPIIS A bovine leukemia virus retropepsin PANKGGGG S tryptase beta 1 (Homo sapiens) PAPFAAAG S streptogrisin B PAVSLAMT A Rous sarcoma virus retropepsin PCPSCPAP C cathepsin L-like endopeptidase (Fasciola sp.) PELFRQFY A phytepsin PETAMSTV S neutrophil elastase PFDLLDFN S cathepsin G PFHLLVHS A renin PFHLLVYG A renin PFHLLVYG M oligopeptidase O PFHLLVYS A pepsin A PFHLLYHN A renin-2 PFHLVIHN A renin

14 PFSPLVAT M stromelysin 1 PGLKIPKE M anthrax lethal factor PGNFLQSR PGQAQVKE M atrolysin E PGQFGRLG A pepsin A PHLSFMAI A endothiapepsin PILFFRLK PIQAFLLY A chymosin PIVFGRLG A plasmepsin 2 PKAKSHAP S plasmin PKRKCCIF C Ulp1 endopeptidase PLIMAVVN A Rous sarcoma virus retropepsin PLPLLQSW A chymosin PMKRLTLG S coagulation factor XIIa PMQADGPR M procollagen C-proteinase PMVGVLDA A bovine leukemia virus retropepsin PNLPLPAQ M enamelysin PPAASSLR M ADAM9 endopeptidase PPEELKFG M stromelysin 1 PPEELKFQ M matrilysin (MMP-7) PPGFSPFR M oligopeptidase F PPMFSMQS M enamelysin PPSPVQQK M stromelysin 1 PPSSLRVT PPTPSPPS S IgA1-specific serine endopeptidase (Neisseria sp.) PPVASSLR M ADAM9 endopeptidase PQAYPIQT A feline immunodeficiency virus retropepsin PQFRIKGG S plasmin PQGDAAQK C endopeptidase 1 (mite) PQGRIVGG S coagulation factor XIIa PQLRMKNN S protein C (activated) PQQFFGLM M coccolysin PQQFFGLM M endothelin-converting enzyme 1 PQVLPVMH A retropepsin (human T-cell leukemia virus) PQVMAAVA A Mason-Pfizer leukemia virus retropepsin PRCRHRPF S plasmin PRERKAGC M nardilysin PRFKIIGG C cathepsin B PRFKIIGG S tryptase alpha PRILMESK A penicillopepsin PRNRGGGG S tryptase beta 1 (Homo sapiens) PRPPAPVF S IgA1-specific serine endopeptidase (Neisseria sp.) PRRPYILG M endothelin-converting enzyme 1 PRSSMSNT M vibriolysin PRTKGGGG S tryptase beta 1 (Homo sapiens) PSHKEGPQ S plasmin PTIFGRLG PTINNVHT A spumapepsin PTLQLPLA M anthrax lethal factor PTVMAVVN A Mason-Pfizer leukemia virus retropepsin

15 PVGKKRRG A yapsin 1 PVILPIQA A retropepsin (human T-cell leukemia virus) PVLPALTI M anthrax lethal factor PVQPIGPQ M collagenase 1 (MMP-1) PYILKRGS A pepsin A PYILKRGS A rhizopuspepsin PYYGDEPM M procollagen C-proteinase QAKRYGGF S proprotein convertase 1 QAQAILQQ QEVYGMMP C calpain-1 QFFGLMGG M endothelin-converting enzyme 1 QGTFTSDY S chymotrypsin A (cattle-type) QIDRIMEK M bontoxilysin QIGGATYG C Ulp1 endopeptidase QKLLSIDL S site-1 protease QKTDTSHH C endopeptidase 1 (mite) QLGRLHMK S complement factor B QLWLTPQQ S lon protease QMGVMQGV M stromelysin 1 QMHALLHQ M matrilysin-2 (MMP-26) QNCPLGGG S prolyl oligopeptidase QPASVSIP QPDAINAP M stromelysin 1 QPDALNVP QPGGINTS QQKLSREW S lon protease QQKRKIVL S complement factor D QRQRIIGG S complement component activated C1r QSHALQPH M enamelysin QSPRSFQK QTLTLRSS M ADAM17 endopeptidase QTQSLVYP M collagenase cola QVSPLTLL M stromelysin 1 RAGRSKGT S proprotein convertase 5 RAIHIQAE M gelatinase B RAIHLQAE RAIRKIAV S infectious pancreatic necrosis birnavirus Vp4 protease RARFSQSI S potyvirus P1 proteinase RAVNTVTQ A spumapepsin RAVYTITP A spumapepsin RDQKLSEL M bontoxilysin RDVRGFAS S furin REKRAVGI S PACE4 proprotein convertase RELGLGRG C calpain-1 RERKAGCK S proprotein convertase 1 RFKIIGGE S neutrophil elastase RGFFYTPK RGLTSLAD S site-1 protease RGRRDFPE S proprotein convertase 1 RHLLGFSA S site-1 protease

16 RILLCVLT M S2P protease RIRPKLKW S prolyl oligopeptidase RKILFLDG RKLKGAGN C foot-and-mouth disease virus L-proteinase RKRKCLLL C Ulp1 endopeptidase RKRRSVNP S furin RKVFRSLK S site-1 protease RLEASSRS S herpesvirus 8-type assemblin RLLKRADG A yapsin 1 RLRKQMAV S tryptase alpha RLVMAQIS A feline immunodeficiency virus retropepsin RPFEVKDT M macrophage elastase RPKLKGGG M angiotensin-converting enzyme 2 RPKRYNSG M russellysin RPPGFSPF M coccolysin RPRRTKKT S proprotein convertase 5 RQANFLGK RQKRFVLS S furin RRLLGTFT S site-1 protease RRLLRAIP S site-1 protease RRLLSEES S site-1 protease RRVLAEAM RSKRSLSC S furin RSLKYAES S site-1 protease RSPFIWNG S chymotrypsin A (cattle-type) RSVLSFES S site-1 protease RSVLSLES S site-1 protease RSYSDRGE M procollagen C-proteinase RTEYLTGV C sindbis virus-type nsp2 proteinase RVAAGEPL S repressor LexA RVAEMRGE M stromelysin 1 RVGFYESD RVKRSLVV S proprotein convertase 4 RVSEMEMA RVSRRSRG A omptin RYSSLTAG M gelatinase A RYTNANTP S chymotrypsin A (cattle-type) SAAPSFDS M stromelysin 1 SAEDDSEQ M PHEX endopeptidase SDMYVHVG C rhinovirus picornain 2A SEAFTVKK S SpoIVB peptidase SEVKMDAE C gingipain K SFFGLEVT M stromelysin 1 SFNFPISP SGAKPRALTA MMP-L6 SGANISDLTA MMP-L9 SGAPLGALTA MMP-L1 SGAWYYVP A phytepsin SGEALRNFTA MMP-L13 SGEALRNLTA MMP-L14

17 SGEALRRLTA MMP-L15 SGEALRYFTA MMP-L16 SGEALSNFTA MMP-L17 SGEALSNLTA MMP-L18 SGEALSRLTA MMP-L19 SGEALSYFTA MMP-L20 SGEALWNFTA MMP-L21 SGEALWNLTA MMP-L22 SGEALWRLTA MMP-L23 SGEALWYFTA MMP-L24 SGEAPRNFTA MMP-L25 SGEAPRNLTA MMP-26 SGEAPRRLTA MMP-L27 SGEAPRYFTA MMP-28 SGEAPSNFTA MMP-L29 SGEAPSNLTA MMP-30 SGEAPSRLTA MMP-L31 SGEAPSYFTA MMP-L32 SGEAPWNFTA MMP-L33 SGEAPWNLTA MMP-34 SGEAPWRLTA MMP-L35 SGEAPWYFTA MMP-L36 SGESLAYYTA MMP-L7 SGESLRNFTA MMP-L37 SGESLRNLTA MMP-L38 SGESLRRLTA MMP-L39 SGESLRYFTA MMP-L40 SGESLRYYTA MMP-L8 SGESLSNFTA MMP-L41 SGESLSNLTA MMP-L42 SGESLSRLTA MMP-L43 SGESLSYFTA MMP-L44 SGESLWNFTA MMP-L45 SGESLWNLTA MMP-L46 SGESLWRLTA MMP-L47 SGESLWYFTA MMP-L48 SGESPRNFTA MMP-L49 SGESPRNLTA MMP-50 SGESPRRLTA MMP-L51 SGESPRYFTA MMP-L52 SGESPSNFTA MMP-53 SGESPSNLTA MMP-54 SGESPSRLTA MMP-55 SGESPSYFTA MMP-56 SGESPWNFTA MMP-L57 SGESPWNLTA MMP-58 SGESPWRLTA MMP-L59 SGESPWYFTA MMP-L60 SGMRVVGG S acrosin SGRALRNFTA MMP-L4

18 SGRALRNLTA MMP-L61 SGRALRRFTA MMP-L62 SGRALRYFTA MMP-L63 SGRALRYLTA MMP-L64 SGRALSNLTA MMP-L65 SGRALSRFTA MMP-L66 SGRALSYFTA MMP-L67 SGRALSYLTA MMP-L68 SGRALWNFTA MMP-L2 SGRALWNLTA MMP-L3 SGRALWRLTA MMP-L69 SGRALWYFTA MMP-L70 SGRAPRNFTA MMP-L71 SGRAPRNLTA MMP-L72 SGRAPRRLTA MMP-L73 SGRAPRYFTA MMP-L74 SGRAPSNFTA MMP-L75 SGRAPSNLTA MMP-76 SGRAPSRLTA MMP-L77 SGRAPSYFTA MMP-L78 SGRAPWNFTA MMP-L79 SGRAPWNLTA MMP-L80 SGRAPWRLTA MMP-L81 SGRAPWYFTA MMP-L82 SGRSLRNFTA MMP-L83 SGRSLRNLTA MMP-L84 SGRSLRRLTA MMP-L11 SGRSLRYFTA MMP-L85 SGRSLRYLTA MMP-L86 SGRSLSNLTA MMP-L87 SGRSLSRFTA MMP-L88 SGRSLSRLTA MMP-L10 SGRSLSYLTA MMP-L89 SGRSLWNFTA MMP-90 SGRSLWRFTA MMP-L91 SGRSLWRLTA MMP-L92 SGRSLWYLTA MMP-L93 SGRSPRNFTA MMP-L94 SGRSPRRFTA MMP-L95 SGRSPRRLTA MMP-L96 SGRSPRYLTA MMP-L97 SGRSPSNFTA MMP-L98 SGRSPSRFTA MMP-L99 SGRSPSRLTA MMP-L100 SGRSPSYFTA MMP-L106 SGRSPSYLTA MMP-L101 SGRSPWNFTA MMP-L102 SGRSPWNLTA MMP-L107 SGRSPWRFTA MMP-L103 SGRSPWRLTA MMP-L104

19 SGRSPWYFTA SGRSPWYLTA SGVQLRRVTA SGVQMLEVTA SHLVEALY SHLVEALY SHLVEALY SHSLLVTL SIAMSRMS SILVTKKF SKMLFVEP SLAYYTAG SLGRKIQI SLLNLNST SLLRSEET SLMKRPPG SLMKRPPG SLRRLTAG SLRYYTAG SLSRLTAG SLTLTDVE SLYQLENY SMTRVVGG SPAYYTAG SPFRSSRI SPFRSVTV SPGRVVGG SPLAQAVR SPLLTQET SPQTGDNS SPVAVSQS SQNFPIVQ SQNLNMDQ SQNYPIVQ SQNYVIVG SQPSGLFK SRVVNGED SSGLYVNP SSNQLQRR STARFTLN STATAAPK STAVIVSA STGRNGFK STPPTPSP STVLTSKY SVESLYQL SVPKRRRK SWIKKRQQ SWIKRKRE SYPEKGGK MMP-L108 MMP-L105 MMP-L12 MMP-L5 S neutrophil elastase M leishmanolysin M gelatinase A (MMP-2) S complement component activated C1s C endopeptidase 1 (mite) S complement factor I S kallikrein hk2 (Homo sapiens) S plasma kallikrein M gelatinase A (MMP-2) M gelatinase A (MMP-2) M gelatinase A (MMP-2) A phytepsin M thermolysin S coagulation factor XIIa M gelatinase A (MMP-2) S kallikrein hk1 S kallikrein mk1 (Mus musculus) S u-plasminogen activator M ADAM9 endopeptidase M matrilysin-2 (MMP-26) C sortase A S plasma kallikrein A pepsin A A HIV-2 retropepsin C nuclear-inclusion-a endopeptidase (plum pox virus) S pancreatic endopeptidase E A thermopsin M envelysin M anthrax lethal factor M Ste24 endopeptidase M matrilysin-2 (MMP-26) S complement factor I M IgA1-specific metalloendopeptidase M thermolysin C foot-and-mouth disease virus L-proteinase C gingipain R C gingipain K M oligopeptidase A

20 TAEEKAAV TALWGKVN TAQEAGEG M ADAMTS4 endopeptidase TDVQGQIT C rhinovirus picornain 3C TEEWSAAP S togavirin TEGEARGS M atrolysin C TFHKAEYR S plasma kallikrein TFIKRFPH S infectious pancreatic necrosis birnavirus Vp4 protease TGRRGSAN S flavivirin TGVSAQVQ C calpain-1 THEKGRQS S plasmin THKRDTYA M O-sialoglycoprotein endopeptidase TIQAASKP S signal peptidase I TKVLVVKP A retropepsin (human T-cell leukemia virus) TKVQVVQS A feline immunodeficiency virus retropepsin TLLIENSS A Moloney murine leukemia virus-type retropepsin TLLSALVE M serralysin TLNEKAVK S subtilisin BPN' TLNFPISP TPLGDTTH C cathepsin L-like endopeptidase (Fasciola sp.) TPNNEIDS C legumain (chordate) TQRFFESF TQTMGPRP C poliovirus-type picornain 2A TRLRKQMA M pitrilysin TRQFFESF TRQLSGLK S lon protease TSDYSKYL S chymotrypsin A (cattle-type) TSEDLVVQ M membrane-type matrix metalloproteinase 1 TSEKSQTP C gingipain K TSLLMAAP A napsin A (human-type) TSTFTNIT C calpain-1 TSTRIVGG S coagulation factor XIIa TSVLMAAP A napsin A (human-type) TTGLPALI TTTRIIGG S coagulation factor B (Limulus, Tachypleus), activated TVAEVTEV TVASSSTA TVGRSGSP S coagulation factor C (horse-shoe crab) activated VAASSLRN M ADAM9 endopeptidase VAKKSVPH S proprotein convertase 2 VAPPSPQA S IgA1-specific serine endopeptidase (Neisseria sp.) VAQDLNAP M stromelysin 1 VAVSAKRE VDPRLIDG VDQRGNQI S protein C (activated) VEALYLVE VEATEFDT A saccharopepsin VEGERGFF VEIDNGKQ C caspase-6 VESESRGA M ADAMTS4 endopeptidase

21 VESQSTLE C hepatitis A virus-type picornain 3C VFRRDAHK S furin VHLEGSHS S neutrophil elastase VHRDMAAR C caspase-9 VIKQGDSW C poliovirus-type picornain 3C VIPRSGGS VKITLLSA S neutrophil elastase VKKRSVSE S proprotein convertase 7 VLGRTQIV S clotting enzyme (Tachypleus) VLSEGGGG C cathepsin X VLSLSSQS A chymosin VMVGMGQK M fragilysin VNQHLEGS M thermolysin VPLSHSRS C cathepsin K VQAAYQKV VQWLMNTG A phytepsin VQWLMNTG S chymotrypsin A (cattle-type) VRTDLAVE VSGRGFSI S clotting enzyme (Tachypleus) VSKRYGGF S proprotein convertase 1 VSNKYFSN S u-plasminogen activator VSQELGQR M ADAMTS4 endopeptidase VSTSGPRA C rhinovirus picornain 2A VTAFWSKV VTALWGKV VTTQVGDD C hepatitis A virus-type picornain 3C VVCCSMSY S hepacivirin VVFSYNTG M stromelysin 1 VVGLSSAE S pestivirus NS3 polyprotein peptidase VVNASCRL S cytomegalovirus assemblin VVPRGVNL VVTQGPEE C rhinovirus picornain 3C VVTRSQEN S proprotein convertase 1 VVYGLRSK VWAAEAIS VYFQGKKN C tobacco etch virus NIa protease VYHQAAGG C nuclear-inclusion-a endopeptidase (plum pox virus) VYHQAWGG C nuclear-inclusion-a endopeptidase (plum pox virus) VYHQTLGG C nuclear-inclusion-a endopeptidase (plum pox virus) VYHQTLNE C nuclear-inclusion-a endopeptidase (plum pox virus) VYIHPFHL A aspergillopepsin I VYSQGEKR C tobacco etch virus NIa protease WAAEAISD WAGGNASG M beta-lytic metalloendopeptidase (myxobacteria) WCILEHNY S cerevisin WGTFEEVS WLQLKPGQ A barrierpepsin WMDFGGGG C calpain-1 WMRFAGGG C cathepsin X WSYGLRPG C calpain-1

22 WVQASGLP S lon protease WYLRSNNG YAPPINHQ YEKGLSLI A type IV prepilin peptidase 1 YELQGPED C calicivirin YENKPRRP C gingipain K YERFNFDG M pappalysin-1 YFLEGGVK S equine arteritis virus serine endopeptidase YGGFLRKY M gametolysin YGGFLRRI M gametolysin YGPKKKRK S granzyme K YGTEFATE YGTEFSTE YIHPFGGG M angiotensin-converting enzyme 2 YIHPFHLG M coccolysin YILKRDSY M nardilysin YIPEWEGR C cathepsin K YKYEIAQE YLDSRRAQ A phytepsin YLKASLIP S herpesvirus 8-type assemblin YLNSILNG M pitrilysin YLQASEKF S assemblin YMRADQAA M procollagen C-proteinase YNVGGMNR C potato virus Y-type helper component proteinase YPKRSSEM S proprotein convertase 2 YQKRYGGF S proprotein convertase 1 YSKYLDSR S chymotrypsin A (cattle-type) YTRLRKQM M pitrilysin YVADAPVE C caspase-1 YVADGGGG C caspase-1 YVHDAPVR C caspase-1 YVICLREN M fragilysin YVKASVSG S cytomegalovirus assemblin YVKASVSP S cytomegalovirus assemblin YVQEGVDA S equine arteritis virus serine endopeptidase YVVNCNTK A spumapepsin YYRADDAN M procollagen C-proteinase