Intervensjon (tiltak) Tillegg av clopidogrel eller antikoagulasjon

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1 Acetylsalisylsyre, clopidogrel og antikoagulasjon PICO 1.4 Kontaktperson: Søk: Kommentar: Tidsbruk: Liv Hege Kateraas og Bent Indredavik Marita Heintz Søk etter systematiske oversikter 25 timer Pico-skjema: Spørsmålet i PICO format Hva handler spørsmålet om? Populasjon (pasient) Intervensjon (tiltak) Comparison (sammenligning/ kontroll) Outcome(s) (utfall/effekt) Har pasienter med TIA/ aktutt hjerneinfarkt som bruker acetylsalisylsyre, effekt av clopidogrel eller antikoagulasjon i TIA/ akutt hjerneinfarkt pasienter som bruker acetylsalicylsyre Tillegg av clopidogrel eller antikoagulasjon Hjerneinfarkt / vaskulære hendelser / død tillegg? Database: Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present Dato: Antall treff: 191 (186 etter sletting av interne dubletter) stroke/ or cerebral infarction/ or dementia, multi-infarct/ or infarction, anterior cerebral artery/ or infarction, middle cerebral artery/ or infarction, posterior cerebral artery/ or stroke, lacunar/ or brain 1 ischemia/ or carotid artery, internal, dissection/ or carotid artery thrombosis/ or "intracranial embolism and thrombosis"/ or intracranial embolism/ or intracranial thrombosis/ or vertebral artery dissection/ (stroke or cerebrovasc* or cerebral vasc*).tw ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA 3 or anterior circulation or posterior circulation or basal ganglia or penumbra) adj5 (isch?emi* or infarct* or thrombo* or emboli*)).tw Ischemic Attack, Transient/ (TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or brain or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw or/

2 7 Aspirin/ or Aspirin, Dipyridamole Drug Combination/ (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 8 9 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina).mp. (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) adj1 acid).mp or/ Ticlopidine/aa [Analogs & Derivatives] 7203 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor 12 Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp exp anticoagulants/ exp Blood Coagulation/ai, de [Antagonists & Inhibitors, Drug Effects] exp Blood Coagulation Factors/ai [Antagonists & Inhibitors] (anticoagul* or antithromb*).tw exp antithrombins/ hirudin therapy/ thrombin/ai [Antagonists & Inhibitors] 3500 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin$ or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil).mp. (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban).mp heparin/ exp heparin, low-molecular-weight/ heparinoids/ 921 (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or 25 tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org or mesoglycan or pentosan polysul* or sp54 or sp-54 or

3 cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*).mp. 26 Factor Xa Inhibitors/ ((("direct thrombin" or "factor xa" or "factor 10a" or fxa or "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") adj2 inhibit*) or xabans).mp exp Vitamin K/ai [Antagonists & Inhibitors] ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K").tw Warfarin/ or 4-hydroxycoumarins/ or acenocoumarol/ or coumarins/ or dicumarol/ or ethyl biscoumacetate/ or phenindione/ or phenprocoumon/ or coumafos/ (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin).mp (((new or novel) adj2 oral anticoagulant*) or NOAC).tw Dabigatran/ or Rivaroxaban/ 2438 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY " or "BAY " or "BAY " or 34 BAY or apixaban or "bms " or bms or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY or darexaban or SSR126517E).mp or/ and 10 and ((systematic* or literature) adj2 review*).mp (metaanalys* or meta analys*).mp. or (meta analysis or review).pt or and limit 40 to yr="2014 -Current" 191

4 Database: Embase 1974 to 2016 May 26 Dato: Antall treff: 247 (235 etter sletting av interne dubletter) cerebrovascular accident/ or brain infarction/ or multiinfarct dementia/ or cerebral artery disease/ or 1 lacunar stroke/ or brain ischemia/ or carotid artery injury/ or carotid artery thrombosis/ or brain embolism/ or occlusive cerebrovascular disease/ or artery dissection/ (stroke or cerebrovasc* or cerebral vasc*).tw ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA 3 or anterior circulation or posterior circulation or basal ganglia or penumbra) adj5 (isch?emi* or infarct* or thrombo* or emboli*)).tw transient ischemic attack/ (TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or brain or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw or/ acetylsalicylic acid/ or acetylsalicylic acid plus dipyridamole/ (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 8 9 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina).mp. (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) adj1 acid).mp or/ clopidogrel/ (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp. exp anticoagulant agent/ or anticoagulant therapy/ or exp thrombin inhibitor/ or exp blood clotting factor 10a inhibitor/ or 4 hydroxycoumarin/ or coumarin/ or coumarin derivative/ (anticoagul* or antithromb*).tw (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or 15 flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin$ or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil).mp

5 (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY or darexaban or 16 edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban).mp. (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*).mp. ((("direct thrombin" or "factor xa" or "factor 10a" or fxa or "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") adj2 inhibit*) or xabans).mp ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K").tw (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione 20 or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin).mp (((new or novel) adj2 oral anticoagulant*) or NOAC).tw (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY " or "BAY " or "BAY " or BAY or apixaban or "bms " or bms or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY or darexaban or SSR126517E).mp or/ and 10 and acetylsalicylic acid plus clopidogrel/ and or meta analysis/ or "systematic review"/ or ((systematic* adj2 review*) or metaanalys* or meta analys*).tw and limit 29 to yr="2014 -Current" 247

6 Database: The Cochrane Library (Cochrane Database of Systematic Reviews: Issue 5 of 12, May 2016; Database of Abstracts of Reviews of Effect: Issue 2 of 4, April 2015; Health Technology Assessment Database: Issue 2 of 4, April 2016, NHS Economic Evaluation Database : Issue 2 of 4, April 2015) Dato: Antall treff: 22 (13 Cochrane, 3 other, 1 tech.ass og 5 eco.eval.) #1 [mh ^stroke] 5845 #2 [mh ^"cerebral infarction"] 541 #3 [mh ^"dementia, multi-infarct"] 62 #4 [mh ^"infarction, anterior cerebral artery"] 4 #5 [mh ^"infarction, middle cerebral artery"] 106 #6 [mh ^"infarction, posterior cerebral artery"] 3 #7 [mh ^"stroke, lacunar"] 19 #8 [mh ^"brain ischemia"] 1216 #9 [mh ^"carotid artery, internal, dissection"] 5 #10 [mh ^"carotid artery thrombosis"] 18 #11 [mh ^"intracranial embolism and thrombosis"] 84 #12 [mh ^"intracranial embolism"] 127 #13 [mh ^"intracranial thrombosis"] 35 #14 [mh ^"vertebral artery dissection"] 7 #15 (stroke or cerebrovasc* or cerebral vasc*):ti,ab,kw in Cochrane Reviews 470 (Reviews and Protocols) #16 (stroke or cerebrovasc* or cerebral vasc*) in Other Reviews, Technology 3235 Assessments and Economic Evaluations #17 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or 135 intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) near/5 (ischemi* or ischaemi* or ischiemi* or ischoemi*or infarct* or thrombo* or emboli*)):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #18 ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or 605 intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) near/5 (ischemi* or ischaemi* or ischiemi* or ischoemi* or infarct* or thrombo* or emboli*)) in Other Reviews, Technology Assessments and Economic Evaluations #19 [mh ^"Ischemic Attack, Transient"] 611 #20 (TIA or TIAs or ((ischemic or ischaemic) next (attack or attack? or seizure or 37 seizure?)) or (transient next (brainstem or brain or "brain stem" or cerebral) next (ischemi* or ischaemi* or ischiemi* or ischoemi*))):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #21 (TIA or TIAs or ((ischemic or ischaemic) next (attack or attack? or seizure or 287 seizure?)) or (transient next (brainstem or brain or "brain stem" or cerebral) next (ischemi* or ischaemi* or ischiemi* or ischoemi*))) in Other Reviews, Technology Assessments and Economic Evaluations #22 [mh ^Aspirin] 4744 #23 [mh ^"Aspirin, Dipyridamole Drug Combination"] 12

7 #24 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum 107 acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #25 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum 864 acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina) in Other Reviews, Technology Assessments and Economic Evaluations #26 (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or 10 acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) near/1 acid):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #27 (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or 76 acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) near/1 acid) in Other Reviews, Technology Assessments and Economic Evaluations #28 MeSH descriptor: [Ticlopidine] this term only and with qualifier(s): [Analogs 1121 & derivatives - AA] #29 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or 47 "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #30 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or 586 "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) in Other Reviews, Technology Assessments and Economic Evaluations #31 [mh anticoagulants] 4435 #32 MeSH descriptor: [Blood Coagulation] explode all trees and with qualifier(s): 1456 [Drug effects - DE] #33 (anticoagul* or antithromb*):ti,ab,kw in Cochrane Reviews (Reviews and 160 Protocols) #34 (anticoagul* or antithromb*) in Other Reviews, Technology Assessments and 1288 Economic Evaluations #35 [mh antithrombins] 578 #36 [mh ^"hirudin therapy"] 79 #37 MeSH descriptor: [Thrombin] this term only and with qualifier(s): [Analogs & 0 derivatives - AA] #38 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or 9

8 hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #39 (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or 171 melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil) in Other Reviews, Technology Assessments and Economic Evaluations #40 (antistasin or apixaban or betrixaban or du 176b or eribaxaban or 15 fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #41 (antistasin or apixaban or betrixaban or du 176b or eribaxaban or 167 fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban) in Other Reviews, Technology Assessments and Economic Evaluations #42 [mh ^heparin] 3103 #43 [mh "heparin, low-molecular-weight"] 1840 #44 [mh ^heparinoids] 54 #45 (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or 116 mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy- 222 or cy216 or cy-216 or dermatan sul* or heparan sul*):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #46 (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or 756 mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy- 222 or cy216 or cy-216 or dermatan sul* or heparan sul*) in Other Reviews, Technology Assessments and Economic Evaluations #47 [mh ^"Factor Xa Inhibitors"] 279 #48 ((("direct thrombin" or "factor xa" or "factor 10a" or fxa or 12 "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") near/2 inhibit*) or xabans):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #49 ((("direct thrombin" or "factor xa" or "factor 10a" or fxa or 63 "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") near/2 inhibit*) or xabans) in Other Reviews, Technology Assessments and Economic Evaluations #50 MeSH descriptor: [Vitamin K] explode all trees and with qualifier(s): 129 [Antagonists & inhibitors - AI] #51 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K"):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) 21

9 #52 ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or 94 "antivitamin K") in Other Reviews, Technology Assessments and Economic Evaluations #53 [mh ^Warfarin] 1355 #54 [mh ^4-hydroxycoumarins] 17 #55 [mh ^acenocoumarol] 111 #56 [mh ^coumarins] 146 #57 [mh ^dicumarol] 22 #58 [mh ^"ethyl biscoumacetate"] 2 #59 [mh ^phenindione] 27 #60 [mh ^phenprocoumon] 87 #61 [mh ^coumafos] 0 #62 (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or 38 dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #63 (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or 474 dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin) in Other Reviews, Technology Assessments and Economic Evaluations #64 (((new or novel) near/2 oral anticoagulant*) or NOAC):ti,ab,kw in Cochrane 9 Reviews (Reviews and Protocols) #65 (((new or novel) near/2 oral anticoagulant*) or NOAC) in Other Reviews, 61 Technology Assessments and Economic Evaluations #66 [mh ^Dabigatran] 90 #67 [mh ^Rivaroxaban] 133 #68 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or 17 rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY " or "BAY " or "BAY " or BAY or apixaban or "bms " or bms or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY or darexaban or SSR126517E):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #69 (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY " or "BAY " or "BAY " or BAY or apixaban or "bms " or bms or eliques or eliquis or edoxaban or lixiana or savaysa or "du 217

10 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY or darexaban or SSR126517E) in Other Reviews, Technology Assessments and Economic Evaluations #70 {or #1-#21} 9717 #71 {or #22-#27} 5306 #72 {or #28-#69} #73 #70 and #71 and # #74 #70 and #71 and #72 Publication Year from 2014 to 2016, in Cochrane Reviews (Reviews and Protocols), Other Reviews, Methods Studies, Technology Assessments and Economic Evaluations 22 Database: CINAHL via EBSCOhost Dato: Antall treff: 26 S30 S23 AND S28 Limiters - Published Date: S29 S23 AND S S28 S24 OR S25 OR S26 OR S27 186,502 S27 TI (((systematic* or literature) N2 review*) ) OR AB (((systematic* or literature) N2 review*) ) 61,727 S26 TI ( (metaanalys* or meta analys*) ) OR AB ( (metaanalys* or meta analys*) ) 18,128 S25 PT systematic review OR PT review OR PT meta analysis 147,200 S24 (MH "Systematic Review") OR (MH "Literature Review") OR (MH "Meta Analysis") 40,255 S23 S6 AND S10 AND S22 1,089 S22 S21 S20 S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 TI ( (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY " or "BAY " or "BAY " or BAY or apixaban or "bms " or bms or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY or darexaban or SSR126517E) ) OR AB ( (dabigatran or "bibr 1048" or bibr1048 or pradax or pradaxa or prazaxa or rendix or "bibr 953" or bibr953 or rivaroxaban or xarelto or "BAY " or "BAY " or "BAY " or BAY or apixaban or "bms " or bms or eliques or eliquis or edoxaban or lixiana or savaysa or "du 176" or "du 176b" or du176 or du176b or antistasin or betrixaban or "du 176b" or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or yagin or "ym 150" or ym150 or LY or darexaban or SSR126517E) ) TI ( (((new or novel) N1 oral anticoagulant*) or NOAC) ) OR AB ( (((new or novel) N1 oral anticoagulant*) or NOAC) ) 22,598 1,

11 S19 S18 S17 S16 S15 S14 TI ( (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin) ) OR AB ( (coumarin* or cumarin* or phenprocoum* or phenprocum* or dicoumar* or dicumar* or acenocoumar* or acenocumar* or fluindione or phenindione or clorindione or ethyl biscoumacetate or diphenadione or marevan or warfarin* or coumadin* or jantoven or lawarin or waran or warfant or adoisine or aldocumar or athrombin* k or carfin or coumafene or coumaphene or kumatox or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfilone or warnerin) ) TI ( ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K") ) OR AB ( ("vitamin K antagonist*" or "vitamink antagonist*" or VKA or VKAs or "antivitamin K") ) TI ( ((("direct thrombin" or "factor xa" or "factor 10a" or fxa or "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") N1 inhibit*) or xabans) ) OR AB ( ((("direct thrombin" or "factor xa" or "factor 10a" or fxa or "autoprothrombin c" or thrombokinase or "activated factor X" or "factor 10") N1 inhibit*) or xabans) ) TI ( (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*) ) OR AB ( (heparin* or lmwh* or enoxaparin* or glycosaminoglycan* or nadroparin* or mesoglycan* or tedelparin* or certoparin or tinzaparin or parnaparin or dalteparin or reviparin or fraxiparin* or danaparoid or lomoparan or org or mesoglycan or pentosan polysul* or sp54 or sp-54 or cy222 or cy-222 or cy216 or cy-216 or dermatan sul* or heparan sul*) ) TI ( (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban) ) OR AB ( (antistasin or apixaban or betrixaban or du 176b or eribaxaban or fondaparinux or idraparinux or otamixaban or razaxaban or rivaroxaban or yagin or ym 150 or ym150 or LY or darexaban or edoxaban or SSR126517E or fidexaban or idrabiotaparinux or letaxaban or tanogitran or taxexaban) ) TI ( (argatroban or MD805 or MD-805 or dabigatran or ximelagatran or melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil) ) OR AB ( (argatroban or MD805 or MD- 805 or dabigatran or ximelagatran or melagatran or efegatran or flovagatran or inogatran or napsagatran or bivalirudin or lepirudin or hirudin* or desirudin or desulfatohirudin or hirugen or hirulog or AZD0837 or bothrojaracin or odiparcil) ) 3, , ,109 S13 TI ( (anticoagul* or antithromb*) ) OR AB ( (anticoagul* or antithromb*) ) 7,876 S12 TI ( (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) ) OR AB ( (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or 1,802

12 S11 grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) ) (MH "Fibrin") OR (MH "Fibrin Fibrinogen Degradation Products") OR (MH "Thrombin/AI") OR (MH "Ticlopidine") OR (MH "Clopidogrel Bisulfate") OR (MH "Anticoagulants+") OR (MH "Blood Coagulation/DE") OR (MH "Blood Coagulation Factors/AI") OR (MH "Heparin") OR (MH "Heparin, Low-Molecular-Weight") OR (MH "Heparinoids") OR (MH "Warfarin") OR (MH "Vitamin K/AI") OR (MH "Dabigatran Etexilate") OR (MH "Rivaroxaban") 16,985 S10 S7 OR S8 OR S9 8,296 S9 S8 TI ( (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) N0 acid) ) OR AB ( (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) N0 acid) ) TI ( (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina) ) OR AB ( (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asasantin or "asasantine lp" or asatard or asawin or aspirin or aspirina) ) 328 5,204 S7 (MH "Aspirin") 6,330 S6 S1 OR S2 OR S3 OR S4 OR S5 59,292 S5 TI ( (TIA or TIAs or ((ischemic or ischaemic) W0 (attack# or seizure#)) or (transient W0 (brainstem or brain or "brain stem" or cerebral) W0 (ischemia# or ischaemia#))) ) OR AB ( (TIA or TIAs or ((ischemic or ischaemic) W0 (attack# or seizure#)) or (transient W0 (brainstem or brain or "brain stem" or cerebral) W0 (ischemia# or ischaemia#))) ) 2,683 S4 (MH "Cerebral Ischemia, Transient") 2,564 S3 S2 S1 TI ( ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) N4 (isch#emi* or infarct* or thrombo* or emboli*)) ) OR AB ( ((brain* or cerebr* or cerebell* or vertebrobasilar or hemispher* or intracran* or intracerebral or MCA or anterior circulation or posterior circulation or basal ganglia or penumbra) N4 (isch#emi* or infarct* or thrombo* or emboli*)) ) TI ( (stroke or cerebrovasc* or cerebral vasc*) ) OR AB ( (stroke or cerebrovasc* or cerebral vasc*) ) (MH "Stroke") OR (MH "Cerebral Ischemia") OR (MH "Dementia, Multi-Infarct") OR (MH "Stroke, Lacunar") OR (MH "Carotid Artery Dissections") OR (MH "Carotid Artery Thrombosis") OR (MH "Intracranial Embolism") OR (MH "Intracranial Embolism and Thrombosis") OR (MH "Intracranial Thrombosis") OR (MH "Vertebral Artery Dissections") OR (MH "Cerebral Arterial Diseases") OR (MH "Arterial Dissections") 7,416 44,592 40,139

13 Database: Epistemonikos Dato: Antall treff: 39 (1 Broad Synthesis, 38 Systematic Review) ((stroke OR cerebrovasc* OR TIA or TIAs or "ischemic attack" or "ischaemic attack" or "ischemic seizure" or "ischaemic seizure") OR ((brain* OR cerebr* OR cerebell* OR vertebrobasilar OR hemispher* OR intracran* OR intracerebral OR infratentorial OR supratentorial OR MCA OR anterior circulation OR posterior circulation OR basal ganglia OR penumbra) AND (ischemia OR ischaemia OR infarct* OR thrombo* OR emboli*))) AND (aspirin or acetylsalicyl*) AND (clopidogrel* or anticoagul* or antithromb* or heparin or "Vitamin K" or "antivitamin K" or acenocoumarol or coumarin* or dicumarol or "ethyl biscoumacetate" or phenindione or phenprocoumon or coumafos or warfarin or dabigatran or rivaroxaban)