Liv Hege Kateraas og Bent Indredavik Astrid Nøstberg Søk etter systematiske oversikter og , språk (engelsk, norsk, svensk og dansk)

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1 Effekt av fortsatt blodtrykksbehandling på overlevelse eller funksjonelt outcome hos pasienter med hjerneslag som allerede har blodtrykksbehandling (PICO 1.8). Kontaktperson: Søk: Avgrensninger: Liv Hege Kateraas og Bent Indredavik Astrid Nøstberg Søk etter systematiske oversikter og , språk (engelsk, norsk, svensk og dansk) Dublettsjekk i EndNote: Før dublettkontroll: 301 Etter dublettkontroll: 227 Pico-skjema: Spørsmålet i PICO format Hva handler spørsmålet om? Hva er effekten av fortsatt blodtrykksbehandling (I og C står omvendt) på overlevelse eller funksjonelt outcome hos pasienter med hjerneslag som allerede har blodtrykksbehandling? Populasjon (pasient) Pasienter med hjerneslag (både infarkt og blødning) og eksisterende blodtrykksbehand ling ved innkomst. Intervensjon (tiltak) Stoppe blodtrykksbehandling ved innkomst Comparison (sammenligning/ kontrolll) Fortsette blodtrykksbehandling under hele oppholdet Ikke tatt med i søket Outcome(s) (utfall/effekt) Overlevelse eller endring i mrs/ NIHSS Ikke tatt med i søket Hjerneblødning utelatt fra søket

2 Database: Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present Antall treff: 60 # Searches Results 1 Stroke/ Brain Infarction/ Cerebral Infarction/ or/ (acute or sudden or abrupt).tw and ((stroke or strokes or apoplexy or cva or cvas or ((cerebr* or brain) adj3 (attack* or insult*))) adj3 (acute or sudden or abrupt)).tw ((brain* or cerebral or artery or subcortical) adj3 infarct* adj3 (acute or sudden or abrupt)).tw or 7 or Blood Pressure/ ((blood or diastolic or systolic) adj2 pressure*).tw exp Antihypertensive Agents/ (hypotensiv* or antihypertensive$1 or anti hypertensive$1 or ((anti hypertensic or antihypertonic or 13 antihypertension) adj3 (agent$1 or drug$1 or treatment* or therap*))).tw or/ and limit 15 to "reviews (best balance of sensitivity and specificity)" ((systematic* or literature) adj2 review*).mp (metaanalys* or meta analys*).mp. or meta analysis.pt. or (medline or cochrane or embase or 18 psycinfo or search*).tw or and or limit 21 to yr="2014 -Current" Animals/ not (Animals/ and Humans/) not limit 24 to (danish or english or norwegian or swedish) 60

3 Database: Embase 1974 to 2016 June 28 Antall treff: 178 # Searches Results 1 cerebrovascular accident/ brain infarction/ or (acute or sudden or abrupt).tw and ((stroke or strokes or apoplexy or cva or cvas or ((cerebr* or brain) adj3 (attack* or insult*))) adj3 (acute or sudden or abrupt)).tw ((brain* or cerebral or artery or subcortical) adj3 infarct* adj3 (acute or sudden or abrupt)).tw or/ blood pressure/ or arterial pressure/ or blood pressure fluctuation/ or blood pressure regulation/ or 9 blood pressure variability/ or diastolic blood pressure/ or orthostatic blood pressure/ or systolic blood pressure/ ((blood or diastolic or systolic) adj2 pressure*).tw exp antihypertensive agent/ (hypotensiv* or antihypertensive$1 or anti hypertensive$1 or ((anti hypertensic or antihypertonic or 12 antihypertension) adj3 (agent$1 or drug$1 or treatment* or therap*))).tw or/ and limit 14 to "reviews (best balance of sensitivity and specificity)" meta analysis/ or "systematic review"/ ((systematic* adj2 review*) or metaanalys* or meta analys*).tw or and or limit 20 to yr="2014 -Current" animal/ not (animal/ and human/) not limit 23 to (danish or english or norwegian or swedish) 178

4 Database: The Cochrane Library: Cochrane Database of Systematic Reviews (CDSR) Issue 6 of 12, June 2016; Database of Abstracts of Reviews of Effect (DARE) Issue 2 of 4, April 2015; Health Technology Assessment Database (HTA) Issue 2 of 4, April 2016 Antall treff: 3 (CDSR: 2, DARE: 1, HTA: 0) ID Search Hits #1 [mh ^Stroke] 5855 #2 [mh ^"Brain Infarction"] 60 #3 [mh ^"Cerebral Infarction"] 542 #4 {or #1-#3} 6382 #5 (acute or sudden or abrupt):ti,ab,kw in Cochrane Reviews (Reviews and Protocols), Trials and Methods Studies #6 (acute or sudden or abrupt) in Other Reviews, Technology Assessments and Economic Evaluations 5723 #7 #4 and (#5 or #6) 1761 #8 ((stroke or strokes or apoplexy or cva or cvas or ((cerebr* or brain) near/3 (attack* or insult*))) near/3 (acute 4619 or sudden or abrupt)):ti,ab,kw in Cochrane Reviews (Reviews and Protocols), Trials and Methods Studies #9 ((stroke or strokes or apoplexy or cva or cvas or ((cerebr* or brain) near/3 (attack* or insult*))) near/3 (acute 280 or sudden or abrupt)) in Other Reviews, Technology Assessments and Economic Evaluations #10 (((brain* or cerebral or artery or subcortical) near/3 infarct*) near/3 (acute or sudden or abrupt)):ti,ab,kw in 888 Cochrane Reviews (Reviews and Protocols), Trials and Methods Studies #11 (((brain* or cerebral or artery or subcortical) near/3 infarct*) near/3 (acute or sudden or abrupt)) in Other 14 Reviews, Technology Assessments and Economic Evaluations #12 {or #7-#11} 6220 #13 [mh ^"Blood Pressure"] #14 ((blood or diastolic or systolic) near/2 pressure*):ti,ab,kw in Cochrane Reviews (Reviews and Protocols), Trials and Methods Studies #15 ((blood or diastolic or systolic) near/2 pressure*) in Other Reviews, Technology Assessments and 1449 Economic Evaluations #16 MeSH descriptor: [Antihypertensive Agents] explode all trees 7267 #17 (hypotensiv* or antihypertensive* or "anti hypertensive" or "anti hypertensives" or (("anti hypertensic" or antihypertonic or antihypertension) near/3 (agent or agents or drug or drugs or treatment* or therap*))):ti,ab,kw in Cochrane Reviews (Reviews and Protocols), Trials and Methods Studies #18 (hypotensiv* or antihypertensive* or "anti hypertensive" or "anti hypertensives" or (("anti hypertensic" or 707 antihypertonic or antihypertension) near/3 (agent or agents or drug or drugs or treatment* or therap*))) in Other Reviews, Technology Assessments and Economic Evaluations #19 {or #13-#18} #20 #12 and #19 455

5 #21 #20 in Cochrane Reviews (Reviews and Protocols), Other Reviews and Technology Assessments 35 #22 #21 Publication Year from 2014 to Database: Cinahl via Ebsco Antall treff: 46 # Query Results S21 S11 OR S19 Limiters - Published Date: S20 S11 OR S S19 S10 AND S18 55 S18 S12 OR S13 OR S14 OR S15 OR S16 OR S17 187,233 S17 TI (((systematic* or literature) N2 review*) ) OR AB (((systematic* or literature) N2 review*) ) 62,016 S16 TI ( (metaanalys* or meta analys*) ) OR AB ( (metaanalys* or meta analys*) ) 18,298 S15 PT systematic review OR PT review OR PT meta analysis 147,439 S14 (MH "Meta Analysis") 17,510 S13 (MH "Literature Review") 3,590 S12 (MH "Systematic Review") 25,882 S11 S4 AND S9 Limiters - Clinical Queries: Review - Best Balance 255 S10 S4 AND S9 541 S9 S5 OR S6 OR S7 OR S8 49,620 S8 TI ( hypotensiv* or antihypertensive# or anti hypertensive# or ((anti hypertensic or antihypertonic or antihypertension) N2 (agent# or drug# or treatment* or therap*)) ) OR AB ( hypotensiv* or antihypertensive# or anti hypertensive# or ((anti hypertensic or antihypertonic or antihypertension) N2 (agent# or drug# or treatment* or therap*)) ) 5,239 S7 (MH "Antihypertensive Agents+") 15,648 S6 S5 TI ( (blood or diastolic or systolic) N2 pressure* ) OR AB ( (blood or diastolic or systolic) N2 pressure* ) (MH "Blood Pressure") OR (MH "Arterial Pressure+") OR (MH "Diastolic Pressure") OR (MH "Systolic Pressure") 28,069 19,529 S4 S1 OR S2 OR S3 7,910 S3 S2 TI ( ((brain* or cerebral or artery or subcortical) N3 infarct*) N3 (acute or sudden or abrupt)) OR AB ( ((brain* or cerebral or artery or subcortical) N3 infarct*) N3 (acute or sudden or abrupt)) TI ((stroke or strokes or apoplexy or cva or cvas or ((cerebr* or brain) N3 (attack* or insult*))) N3 (acute or sudden or abrupt)) OR AB ((stroke or strokes or apoplexy or cva or cvas or ((cerebr* or brain) N3 (attack* or insult*))) N3 (acute or sudden or abrupt)) 315 6,242 S1 (MH "Stroke") AND (TI ( acute or sudden or abrupt ) OR AB ( acute or sudden or abrupt )) 6,140

6 Database: Epistemonikos Antall treff: 14 (title:(((stroke OR strokes OR apoplexy OR cva OR cvas OR "brain attack" OR "brain attacks" OR "brain insult" OR "brain insults" OR "cerebral attack" OR "cerebral attacks" OR "cerebral insult" OR "cerebral insults" OR "brain infarction" OR "brain infarct" OR "cerebral infarction" OR "cerebral infarct" OR "artery infarction" OR "artery infarct" OR "subcortical infarction" OR "subcortical infarct") AND (acute OR sudden OR abrupt)) AND ("blood pressure" OR "blood pressures" OR "diastolic pressure" OR "diastolic pressures" OR "systolic pressure" OR "systolic pressures" OR hypotensive OR hypotensives OR antihypertensive OR antihypertensives OR "anti hypertensive" OR "anti hypertensives" OR "anti hypertensic agent" OR "anti hypertensic agents" OR "antihypertonic agent" OR "antihypertonic agents" OR "anti hypertensic drug" OR "anti hypertensic drugs" OR "antihypertonic drug" OR "antihypertonic drugs" OR "anti hypertensic treatment" OR "anti hypertensic treatments" OR "antihypertonic treatment" OR "antihypertonic treatments" OR "anti hypertensic therapy" OR "anti hypertensic therapies" OR "antihypertonic therapy" OR "antihypertonic therapies" OR "antihypertension agent" OR "antihypertension agents" OR "antihypertension drug" OR "antihypertension drugs" OR "antihypertension treatment" OR "antihypertension treatments" OR "antihypertension therapy" OR "antihypertension therapies")) OR abstract:(((stroke OR strokes OR apoplexy OR cva OR cvas OR "brain attack" OR "brain attacks" OR "brain insult" OR "brain insults" OR "cerebral attack" OR "cerebral attacks" OR "cerebral insult" OR "cerebral insults" OR "brain infarction" OR "brain infarct" OR "cerebral infarction" OR "cerebral infarct" OR "artery infarction" OR "artery infarct" OR "subcortical infarction" OR "subcortical infarct") AND (acute OR sudden OR abrupt)) AND ("blood pressure" OR "blood pressures" OR "diastolic pressure" OR "diastolic pressures" OR "systolic pressure" OR "systolic pressures" OR hypotensive OR hypotensives OR antihypertensive OR antihypertensives OR "anti hypertensive" OR "anti hypertensives" OR "anti hypertensic agent" OR "anti hypertensic agents" OR "antihypertonic agent" OR "antihypertonic agents" OR "anti hypertensic drug" OR "anti hypertensic drugs" OR "antihypertonic drug" OR "antihypertonic drugs" OR "anti hypertensic treatment" OR "anti hypertensic treatments" OR "antihypertonic treatment" OR "antihypertonic treatments" OR "anti hypertensic therapy" OR "anti hypertensic therapies" OR "antihypertonic therapy" OR "antihypertonic therapies" OR "antihypertension agent" OR "antihypertension agents" OR "antihypertension drug" OR "antihypertension drugs" OR "antihypertension treatment" OR "antihypertension treatments" OR "antihypertension therapy" OR "antihypertension therapies"))) from 2014 to 2016