Mekoprop-P Fane 1 - Preparat Handelsnavn: Duplosan Meko, D. Super m.fl. Herbicid Tester CasNr: 16484-77-8 Test-type Test-varighet µg/l Art Litteratur PNEC1 PNEC2 Alger akutt Alger kronisk Dafnia akutt Dafnia kronisk Fisk akutt Fisk kronisk 72h LC50 270000 1 72h NOEC 27000 1 48h LC50 120000 1 21d NOEC 100000 1 96h LC50 120000 1 28d NOEC 100000 1 Basert på µg/l Usikkerhetsfaktor Verdi (µg/l) AMF basert på PNEC1 Laveste L(EC)50 100000 1000 100 MF basert på PNEC2 LavesteNOEC 27000 100 270 Vurderingsgrunnlag for usikkerhetsfaktor: Tidligere MFI Fane 2 - Tester Alle tester Test-type Test-varighet µg/l Art Litteratur Vis Alger akutt Alger kronisk Dafnia akutt Dafnia kronisk Fisk akutt Fisk kronisk 72h LC50 270000 1 72h NOEC 27000 1 48h LC50 120000 1 21d NOEC 100000 1 96h LC50 120000 1 28d NOEC 100000 1 Fane 3 - Kommentarer Fane 4 - Referanser Litteraturreferanser LokalRefnr Referanse 1 Biologische Bundesanstalt fut Land- und Forstwirtschaft. BBA-Nr. 772. 2006 Fane 5 - Diverse info om preparatet Godkjenelsesdato: 2005 Fornyet godkjenning: Trukket (dato): SpesialAnalyse Metode: 3 M60 Bestemmelsesgrense: 0,01 GC-MULTI
Mekoprop-P Dato siste gjennomgang: Kommentarer Både The Pesticide Manual og den svenske databasen vurderer Mekoprop og Mekoprop P til å ha same økotoksikologiske effekt og har derfor same vurderingen av begg to. Kjemisk konfigurasjonsformel se Mekoprop.Den store forskjellen mellom Mekoprop og Mekoprop-P er at Mekoprop er vurdert opp mot vannplanter, mens den Tyske basen ikke har med denne kategorien.
Vedlegg for Mekoprop Kilde: Svensk undersøkelse 2004 1. Mecoprop, mecoprop-p Mecoprop is an auxin type systemic herbicide, intended for weed control in cereals and pastures. Mecoprop and mecoprop-p are under evaluation within the framework of EU Dir. 91/414. Cl OCHCO 2 H Cl O C CO2 H Mecoprop H Mecoprop-p 1.1 Physico-chemical properties Physico-chemical properties of mecoprop and mecoprop-p are summarised in table 1.1. Table 1.1: Physico-chemical properties of mecoprop and mecoprop-p. Mecoprop Mecoprop-p Reference CAS-No. 7085-19-0 16484-77-8 1, 2 Empirical formula C 10 H 11 ClO 3 C 10 H 11 ClO 3 1, 2 Molecular weight [g/mol] 214.65 214.65 1, 2 Solubility in water [mg/kg] 734 at 25 C 860 at 20 C 1, 2 pka 3.78 3.68 at 20 C 4 Vapour pressure [Pa] 0.12 at 22.5 C 4.0 10-4 at 20 C 1, 2 Log P ow 1.18 at 23 C 1.43 at ph 5, 20 C 0.02 at ph 5, 20 C 1, 2 Henry s law constant [Pa m 3 /mol] -0.18 at ph 5, 20 C 3.51 10-2 at 25 C 9.98 10-5 at 20 C 1, 2 1.2 Toxicity to aquatic organisms The toxicity of mecoprop and mecoprop-p to aquatic organisms is summarised in table 1.2. Table 1.2: Aquatic ecotoxicity data of mecoprop and mecoprop-p. Species End-point Exposure duration Result [mg as/l] Reference Algae Pseudokirchneriella Subcapitata 70 h, static -P EC 50 270 NOEC 27 Anabaena flos-aquae growth rate 72 h E r C 50 23.9 NOEC 6.0 Higher aquatic plant Lemna minor frond numbers 14 d EC 50 1.6 3) Crustaceans LOEC 0.44 2 5 5
Daphnia magna 48 h, static EC 50 >100 3 Daphnia magna 48 h, static EC 50 >100 1 Daphnia magna 48 h, static EC 50 >91 1 Daphnia magna reproduction 21 d, semi-static NOEC 50 2 -P Daphnia magna reproduction 28 d, semi-static NOEC 22.2 1) 1 Fish Oncorynchus mykiss mortality 96 h, static LC 50 124.8 3 Lepomis mortality 96 h, static LC 50 >69 1,2) 3 macrochirus Oncorynchus mykiss mortality 96 h, static LC 50 69 1,2) 3 Oncorynchus mykiss mortality 96 h, flow through LC 50 198 1) 1 Cyprinus carpio mortality 96 h, static LC 50 264-469 1) 1 Oncorynchus mykiss mortality 96 h, static LC 50 147-215 1 Oncorynchus mykiss mortality 96 h, static LC 50 147-215 2 -P Lepomis mortality 96 h, static LC 50 100 1 macrochirus Oncorynchus mykiss 21 d, flow through NOEC >89 1) 1 Oncorynchus mykiss sub lethal 28 d, flow through -P NOEC 50 2 1) Test performed on salt compound. Value expressed as active substance. 2) Test performed on substance with purity <90%. Value expressed as active substance. 3) Effect concentration basis for calculation of PNEC. Test substance purity 68.4% The most sensitive (acute effects) group of species were Lemna minor, with an EC 50 of 1.6 mg/l and NOEC of 0.4 mg/l. Since the acute/chronic ratio is low and does not guarantee appropriate protection against acute effects, the PNEC is based on acute toxicity data. Hence, the lowest EC 50 of 1.6 mg/l is divided by a factor of 100, which results in a PNEC of 0.016 mg/l. 1.3 Bioaccumulation and persistence Mecoprop and mecoprop-p are expected to have a low bioaccumulation potential. The degradation time is approximately 20 days in water (laboratory conditions, 20 C). In water/sediment systems the main portion of mecoprop and mecoprop-p is located in the water phase (1,2). 1.4 Proposed water quality objective Since PNEC is 0.016 mg/l, the proposed water quality objective for mecoprop and mecoprop-p is 0.02 mg/l.
1.5 Comments Mecoprop-p does not show more or higher ecotoxicological effects than racemic mecoprop. Degradation route and major metabolites are unknown. Mecoprop and mecoprop-p may reach surface- and ground waters through the soil profile (1,2). 1.6 Literature (1) European Commission Peer Review Programme. Mecoprop Monograph, 1999. (2) European Commission Peer Review Programme. Mecorop-P Monograph, 1998. (3) Pesticide Ecotoxicity Database, 2001. Environmental Fate and Effects Division of the Office of Pesticide Programs, U.S. EPA. Washington DC. (4) Tomlin, C., 2000. The Pesticide Manual, 12 th edition. British Crop Protection Council. (5) European Commission Peer Review Programme. Mecoprop-p Review report, 2003,