Effekt av ASA som monoterapi vs. ASA/dipyridamol eller clopidogrel alene (PICO 2.8).

Transkript

1 Effekt av ASA som monoterapi vs. ASA/dipyridamol eller clopidogrel alene (PICO 2.8). Kontaktperson: Søk: Avgrensninger: Liv Hege Kateraas og Bent Indredavik Astrid Nøstberg Søk etter systematiske oversikter Dublettsjekk i EndNote: Før dublettkontroll: 502 Etter dublettkontroll: 372 Pico-skjema: Spørsmålet i PICO format Hva handler spørsmålet om? Er ASA som monoterapilike effektiv som ASA/dipyridamol eller clopidogrel alene? Populasjon (pasient) Pasienter medhjerneinfarkt eller TIA uten indikasjon for antikoagulasjon Intervensjon (tiltak) ASA alene Comparison (sammenligning/ kontrolll) ASA/dipyridamol eller clopidogrel Outcome(s) (utfall/effekt) Recidiv hjerneinfarkt,død, blødningskomplik asjoner Database: Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Present Antall treff: 134 # Searches Results 1 brain infarction/ or exp cerebral infarction/ (((cerebr* or brain* or choroidal artery or subcortical) adj3 infarct*) or lacunar dementia* or ((multi 2 infarct or multiinfarct) adj2 dementia*) or ((aca or mca or pca or heubner* artery) adj3 infarct*) or (cerebral artery adj3 (occlusion* or embol* or stroke* or syndrome* or thrombos*))).tw Ischemic Attack, Transient/ (TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or brain or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw or/ Aspirin/ (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 60025

2 8 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asatard or asawin or aspirin or aspirina).mp. (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) adj1 acid).mp or/ Aspirin, Dipyridamole Drug Combination/ (aspirin adj3 dipyridamole adj3 combinat*).tw (asasantin or "asasantine lp").mp Ticlopidine/aa [Analogs & Derivatives] 7482 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp. 15 or/ and 9 and ((systematic* or literature) adj2 review*).mp (metaanalys* or meta analys*).mp. or meta analysis.pt. or (medline or cochrane or embase or 18 psycinfo or search*).tw or and Database: Embase 1974 to 2016 September 22 Antall treff: 262 # Searches Results 1 brain infarction/ or brain infarction size/ or multiinfarct dementia/ (((cerebr* or brain* or choroidal artery or subcortical) adj3 infarct*) or lacunar dementia* or ((multi 2 infarct or multiinfarct) adj2 dementia*) or ((aca or mca or pca or heubner* artery) adj3 infarct*) or (cerebral artery adj3 (occlusion* or embol* or stroke* or syndrome* or thrombos*))).tw transient ischemic attack/ (TIA or TIAs or ((ischemic or ischaemic) adj (attack? or seizure?)) or (transient adj (brainstem or brain 27025

3 or "brain stem" or cerebral) adj (ischemia? or ischaemia?))).tw. 5 or/ acetylsalicylic acid/ (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 7 8 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asatard or asawin or aspirin or aspirina).mp. (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) adj1 acid).mp or/ acetylsalicylic acid plus dipyridamole/ (aspirin adj3 dipyridamole adj3 combinat*).tw (asasantin or "asasantine lp").mp Ticlopidine/ or acetylsalicylic acid plus clopidogrel/ or clopidogrel/ (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099).mp. 15 or/ and 9 and meta analysis/ or "systematic review"/ ((systematic* adj2 review*) or metaanalys* or meta analys*).tw or and

4 Database: The Cochrane Library: Cochrane Database of Systematic Reviews (CDSR) Issue 9 of 12, September 2016; Database of Abstracts of Reviews of Effect (DARE) Issue 2 of 4, April 2015; Health Technology Assessment Database (HTA) Issue 3 of 4, July 2016; NHS Economic Evaluation Database Issue 2 of 4, April 2015 Antall treff: 48 (CDSR: 20, DARE: 17, HTA: 2, EED:9) ID Search Hits #1 [mh ^"brain infarction"] 61 #2 [mh "cerebral infarction"] 715 #3 (((cerebr* or brain* or "choroidal artery" or subcortical) near/3 infarct*) or "lacunar dementia*" or (("multi 57 infarct" or multiinfarct) near/2 dementia*) or ((aca or mca or pca or (heubner* next artery)) near/3 infarct*) or ("cerebral artery" near/3 (occlusion* or embol* or stroke* or syndrome* or thrombos*))):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #4 (((cerebr* or brain* or "choroidal artery" or subcortical) near/3 infarct*) or "lacunar dementia*" or (("multi 173 infarct" or multiinfarct) near/2 dementia*) or ((aca or mca or pca or (heubner* next artery)) near/3 infarct*) or ("cerebral artery" near/3 (occlusion* or embol* or stroke* or syndrome* or thrombos*))) in Cochrane Reviews (Protocols only), Other Reviews, Technology Assessments and Economic Evaluations #5 [mh ^"Ischemic Attack, Transient"] 623 #6 (TIA or TIAs or ((ischemic or ischaemic) next (attack? or seizure?)) or (transient next (brainstem or brain or 31 "brain stem" or cerebral) next (ischemia? or ischaemia?))):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #7 (TIA or TIAs or ((ischemic or ischaemic) next (attack? or seizure?)) or (transient next (brainstem or brain or 115 "brain stem" or cerebral) next (ischemia? or ischaemia?))) in Cochrane Reviews (Protocols only), Other Reviews, Technology Assessments and Economic Evaluations #8 {or #1-#7} 1599 #9 [mh ^aspirin] 4799 #10 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 110 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asatard or asawin or aspirin or aspirina):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #11 (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum 861 acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asatard or asawin or aspirin or aspirina) in Cochrane Reviews (Protocols only), Other Reviews, Technology Assessments and Economic Evaluations #12 (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or 10 acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) near/1 acid):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #13 (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or 78 acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or

5 acetylsalicyclic) near/1 acid) in Cochrane Reviews (Protocols only), Other Reviews, Technology Assessments and Economic Evaluations #14 {or #9-#13} 5360 #15 [mh ^"Aspirin, Dipyridamole Drug Combination"] 12 #16 (asasantin or "asasantine lp" or ((aspirin near/3 dipyridamole) near/3 combinat*)):ti,ab,kw in Cochrane 2 Reviews (Reviews and Protocols) #17 (asasantin or "asasantine lp" or ((aspirin near/3 dipyridamole) near/3 combinat*)) in Cochrane Reviews 8 (Protocols only), Other Reviews, Technology Assessments and Economic Evaluations #18 MeSH descriptor: [Ticlopidine] this term only and with qualifier(s): [Analogs & derivatives - AA] 1165 #19 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor 48 Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099):ti,ab,kw in Cochrane Reviews (Reviews and Protocols) #20 (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor 588 Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) in Cochrane Reviews (Protocols only), Other Reviews, Technology Assessments and Economic Evaluations #21 {or #15-#20} 1692 #22 #8 and #14 and #21 79 #23 #22 in Cochrane Reviews (Reviews and Protocols), Other Reviews, Technology Assessments and 48 Economic Evaluations

6 Database: Cinahl via Ebsco Antall treff: 33 # Query Results S20 S14 AND S19 33 S19 S15 OR S16 OR S17 OR S18 189,527 S18 TI (((systematic* or literature) N2 review*) ) OR AB (((systematic* or literature) N2 review*) ) 63,267 S17 TI ( (metaanalys* or meta analys*) ) OR AB ( (metaanalys* or meta analys*) ) 18,878 S16 (PT systematic review) OR (PT review) OR (PT meta analysis) 147,847 S15 (MH "Systematic Review") OR (MH "Literature Review") OR (MH "Meta Analysis") 41,186 S14 S5 AND S9 AND S S13 S10 OR S11 OR S12 2,836 S12 TI ( (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) ) OR AB ( (clopidogrel* or Iscover or Plavix or "Platelet Aggregation Inhibitors" or "Purinergic P2Y Receptor Antagonists" or clopilet or grepid or zopya or zylagren or zyllt or duocover or duoplavin or "SC 25989C" or SC25989C or "SC 25990C" or SC25990C or "SR 25989*" or SR25989* or "SR 25990C" or SR25990C or "PCR 4099" or PCR4099) ) 1,830 S11 (MH "Ticlopidine") OR (MH "Clopidogrel Bisulfate") 2,350 S10 TI ( (asasantin or "asasantine lp" or ((aspirin N2 dipyridamole) N2 combinat*)) ) OR AB ( (asasantin or "asasantine lp" or ((aspirin N2 dipyridamole) N2 combinat*)) ) 37 S9 S6 OR S7 OR S8 8,417 S8 S7 TI ( (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) N0 acid) ) OR AB ( (("ortho acetoxybenzoic" or "ortho acetyloxybenzoic" or acetylsalicylic or acetylsalycic or acetylsalycylic or acetosalicylic or "2 acetoxybenzoic" or "acetyl salicylic" or "acetylic salicylic" or acetylosalicylic or acetylsalicyclic) N0 acid) ) TI ( (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asatard or asawin or aspirin or aspirina) ) OR AB ( (acetylsalicyl or acetylsalicylate or acetysal or acidulatum or "acidum acetylosalicylicum" or "acidum acetylsalicylicum" or albyle or "albyl e" or "alka seltzer" or asatard or asawin or aspirin or aspirina) ) 340 5,291 S6 (MH "Aspirin") 6,398 S5 S1 OR S2 OR S3 OR S4 11,449 S4 TI ( (TIA or TIAs or ((ischemic or ischaemic) W0 (attack# or seizure#)) or (transient W0 (brainstem or brain or "brain stem" or cerebral) W0 (ischemia# or ischaemia#))) ) OR AB ( (TIA or TIAs or ((ischemic or ischaemic) W0 (attack# or seizure#)) or (transient W0 (brainstem or brain or "brain stem" or cerebral) W0 (ischemia# or ischaemia#))) ) 2,756 S3 (MH "Cerebral Ischemia, Transient") 2,610 S2 TI ( (((cerebr* or brain* or choroidal artery or subcortical) N2 infarct*) or lacunar dementia* or ((multi infarct or multiinfarct) N1 dementia*) or ((aca or mca or pca or heubner* artery) N2 infarct*) or (cerebral artery N2 (occlusion* or embol* or stroke* or syndrome* or thrombos*))) ) 3,295

7 OR AB ( (((cerebr* or brain* or choroidal artery or subcortical) N2 infarct*) or lacunar dementia* or ((multi infarct or multiinfarct) N1 dementia*) or ((aca or mca or pca or heubner* artery) N2 infarct*) or (cerebral artery N2 (occlusion* or embol* or stroke* or syndrome* or thrombos*))) ) S1 (MH "Cerebral Ischemia") OR (MH "Dementia, Multi-Infarct") 5,678 Database: Epistemonikos Antall treff: (3 Broad Synthesis, 1 Structured Summary, 21 Systematic Review) title/abstract: (((cerebr* or brain* or "choroidal artery" or subcortical or aca or mca or pca or heubner*) and infarct*) or "lacunar dementia" or "multi infarct dementia" or "multiinfarct dementia" or "cerebral artery occlusion" or "cerebral artery embolism" or "cerebral artery stroke" or "cerebral artery syndrome" or "cerebral artery thrombosis" or TIA or TIAs or "ischemic attack" or "ischemic attacks" or "ischaemic attack" or "ischaemic attacks" or "ischemic seizure" or "ischaemic seizure" or "transient brainstem ischemia" or "transient brainstem ischaemia" or "transient brain ischemia" or "transient brain ischaemia" or "transient brain stem ischemia" or "transient brain stem ischaemia" or "transient cerebral ischemia" or "transient cerebral ischaemia") AND (aspirin or acetylsalicyl*) AND ("aspirin dipyridamole combination" or "aspirin dipyridamole" or "dipyridamole combination" or asasantin* or clopidogrel* or ticlopidine)