Søk Finn patenter, varemerker og design i Norge Nøkkelinformasjon Databasen er sist oppdatert 2017.06.10 12:06:00 Tittel Status Hovedstatus Detaljstatus Patentnummer Europeisk (EP) publiserings nummer ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) I kraft 2016.07.11 EP patent gjort gjeldende i Norge 2016.07.11 EP patent besluttet gjeldende i Norge NO/EP2215124 EP2215124 EP inngitt 2008.08.22 EP søknadsnummer 08798550.3 EP meddelt 2016.02.24 Prioritet Sakstype 2007.08.23, 957668 P,, med flere Europeisk Løpedag 2008.08.22 Utløpsdato 2028.08.22 Allment tilgjengelig 2010.08.11 Validert i Norge 2016.07.11 Innehaver Oppfinner Fullmektig Supplerende beskyttelsessertifikat(spc) Amgen Inc. () JACKSON, Simon, Mark () Bryn Aarflot AS (NO) 2016010 2016015 Lenke til European patent Register Informasjon i saken, dokumenter og patentfamilie Patentfamilie Se i Espacenet Sammendrag og figur Se forsidefigur og sammendrag i Espacenet Klasser IPC-klasse C07K 16/40 A61K 31/22 A61K 31/366 A61K 31/40 A61K 31/405 A61K 31/44 A61K 31/47 A61K 31/505
A61K 31/66 A61K 39/00 A61K 39/395 A61K 45/06 A61P 3/06 C12N 15/113 Søker Innehaver Innehaver i EP: Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799 Oppfinner JACKSON, Simon, Mark 2071 Birch Avenue San Carlos, CA 94070 WALKER, Nigel Pelham, Clinton 20 Howland Hill Lane Burlingame, CA 94010-6033 PIPER, Derek, Evan 675 Giannini Drive Santa Clara, CA 95051 SHAN, Bei 349 Quay Lane Redwood City, CA 94065 SHEN, Wenyan 60 Pugh Road Wayne, PA 19087 CHAN, Joyce Chi, Yee 314 College Avenue San Francisco, CA 94112 KING, Chadwick, Terence 1325 Moody AvenueNorth Vancouver British Columbia V7L 3T5 CA KETCHEM, Randal, Robert 6332 152nd St. Se Snohomish, WA 98296 MEHLIN, Christopher 2806 Northwest 61st Street Seattle, WA 98107
CARABEO, Teresa, Arazas 1 Christopher Street, Apt. 8A New York, NY 10014 CAO, Qiong 582 King Drive, Apt. 6 Dalt City, CA 94015 Fullmektig Fullmektig i Norge: Bryn Aarflot AS Se mer Postboks 449 Sentrum 0104 OSLO NO ( OSLO kommune, OSLO fylke ) Org.nummer: 979993269 Referanse på sak: 126049 EH Fullmektig i EP: Dörries, Hans Ulrich df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbb Theatinerstrasse 16 80333 München DE Prioritet 2007.08.23, 957668 P 2007.12.21, 8965 P 2008.01.09, 10630 P 2008.08.04, 86133 P Anførte dokumenter "Third Report of tho National Choiesterol Education Progiam (NCEP) Ecpert Panelon Detection. Evaluation, and Treatment cf High Blood Cholesterol in Mults (AdultTreatment Panel IH) Final Report", 1 September 2002 (2002-09-01) pages 3161-3167, (B1) WO-A-2008/133647 (B1) DA-WEI ZHANG ET AL: "Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation*", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY,, vol. 282, no. 25, 22 June 2007 (2007-06-22), pages 18602-18612, XP007912352, ISSN: 0021-9258, DOI: 10.1074/JBC.M702027200 [retrieved on 2007-04-23] (B1) EP-A2-2 615 114 (B1) GROZDANOV PETAR N ET AL: "Expression and localization of PCSK9 in rat hepatic cells" BIOCHEMISTRY AND CELL BIOLOGY. BIOCHIMIE ET BIOLOGIE CELLULAIRE, XX, XX, vol. 84, no. 1, 1 February 2006 (2006-02-01), pages 80-92, XP008095646 ISSN: 0829-8211 (B1) HYOCK JOO KWON ET AL: "Molecular basis for LDL receptor recognition by PCSK9", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES,, vol. 105, no. 6, 12 February 2008 (2008-02-12), pages 1820-1825, XP007912351, ISSN: 0027-8424, DOI: 10.1073 PNAS.0712064105 (B1) LAGACE THOMAS A ET AL: "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice" JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION,, vol. 116, no. 11, 1 November 2006 (2006-11-01), pages 2995-3005, XP002493243 ISSN: 0021-9738 (B1) LAGACE THOMAS A ET AL: "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION,, vol. 116, no. 11, 1 November 2006 (2006-11-01), pages 2995-3005, XP002493243, ISSN: 0021-9738, DOI: 10.1172/JCI29383 (B1) MAXWELL KARA N ET AL: "Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF A, NATIONAL ACADEMY OF SCIENCE,
WASHINGTON, DC.;, vol. 101, no. 18, 4 May 2004 (2004-05-04), pages 7100-7105, XP002493244 ISSN: 0027-8424 (B1) NI YAN G ET AL: "A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, BETHESDA, MD, A, vol. 285, no. 17, 23 April 2010 (2010-04-23), pages 12882-12891, XP002619048, ISSN: 1083-351X, DOI: 10.1074/JBC.M110.113035 [retrieved on 2010-02-19] (B1) RASHID S ET AL: "Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF A, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.;, vol. 102, no. 15, 12 April 2005 (2005-04-12), pages 5374-5379, XP002478031 ISSN: 0027-8424 (B1) Saurabh Saha ET AL: "Solution Structure of the LDL Receptor EGF-AB Pair", STRUCTURE, vol. 9, no. 6, 1 June 2001 (2001-06-01), pages 451-456, XP055229481, ISSN: 0969-2126, DOI: 10.1016/S0969-2126(01)00606-2 (B1) Steven Malby ET AL: "The First Epidermal Growth Factor-like Domain of the Low-Density Lipoprotein Receptor Contains a Noncanonical Calcium Binding Site +", Biochemistry, vol. 40, no. 8, 1 February 2001 (2001-02-01), pages 2555-2563, XP055229482, ISSN: 0006-2960, DOI: 10.1021/bi002322l (B1) WO-A-2008/057457 (B1) WO-A-2008/057458 (B1) WO-A-2008/057459 (B1) WO-A-2008/063382 (B1) WO-A-2008/125623 (B1) BENJANNET SUZANNE ET AL: "The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications." 13 October 2006 (2006-10-13), THE JOURNAL OF BIOLOGICAL CHEMISTRY 13 OCT 2006, VOL. 281, NR. 41, PAGE(S) 30561-30572, XP002506016 ISSN: 0021-9258 see "experimental procedures - anti PCSK9 antibodies" page 30562 (B1) Lisens Pant Klage til Klagenemnda Administrativ prøving Innsigelse Protest / Oppreisning Sakshistorikk Statushistorie Hovedstatus Beslutningsdato, detaljstatus 2016.07.11 EP patent gjort gjeldende i Norge 2016.07.11 EP patent besluttet gjeldende i Norge 2016.05.10 EP under behandling 2016.05.11 Forespørsel om å gjøre EP patent gyldig er mottatt Korrespondanse Dato Type korrespondanse Journal beskrivelse 2017.01.04 Innkommende EP Publiseringsdokument fra EPO 2016.12.28 Innkommende EP Publiseringsdokument fra EPO 2016.07.13 Utgående EP Registreringsbrev (3210) 2016.05.10 Innkommende, AR146777255 Søknadsskjema Patent 2016.03.30 Innkommende EP Publiseringsdokument fra EPO Informasjon om ikke tilgjengelige dokumenter
Betaling Til betaling: Beskrivelse Forfallsdato Beløp Status Årsavgift 2017.08.31 Ikke betalt Årsavgift 10. avg. år (EP) 3200 Totalbeløp 3200 Betalingshistorikk: Beskrivelse / Fakturanummer Betalingsdato Beløp Betaler Status Årsavgift 9. avg. år (EP) 2016.08.12 2850 CPA GLOBAL LTD Betalt og godkjent 31608000 2016.05.25 5500 Bryn Aarflot AS Betalt Denne oversikten kan mangle informasjon, spesielt for eldre saker, internasjonale varemerker og internasjonale design. Publikasjon(er) Lenker til publikasjoner og Norsk Patenttidende (søkbare tekstdokumenter) Oversettelse av europeisk patentskrift Norsk Patenttidende (ved meddelelse) Lenker til publikasjoner (ikke søkbare tekstdokumenter) B1/EP Hva betyr A1, B, B1, C osv?