72h LC h NOEC h LC d NOEC h LC d NOEC

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1 Mekoprop-P Fane 1 - Preparat Handelsnavn: Duplosan Meko, D. Super m.fl. Herbicid Tester CasNr: Test-type Test-varighet µg/l Art Litteratur PNEC1 PNEC2 Alger akutt Alger kronisk Dafnia akutt Dafnia kronisk Fisk akutt Fisk kronisk 72h LC h NOEC h LC d NOEC h LC d NOEC Basert på µg/l Usikkerhetsfaktor Verdi (µg/l) AMF basert på PNEC1 Laveste L(EC) MF basert på PNEC2 LavesteNOEC Vurderingsgrunnlag for usikkerhetsfaktor: Tidligere MFI Fane 2 - Tester Alle tester Test-type Test-varighet µg/l Art Litteratur Vis Alger akutt Alger kronisk Dafnia akutt Dafnia kronisk Fisk akutt Fisk kronisk 72h LC h NOEC h LC d NOEC h LC d NOEC Fane 3 - Kommentarer Fane 4 - Referanser Litteraturreferanser LokalRefnr Referanse 1 Biologische Bundesanstalt fut Land- und Forstwirtschaft. BBA-Nr Fane 5 - Diverse info om preparatet Godkjenelsesdato: 2005 Fornyet godkjenning: Trukket (dato): SpesialAnalyse Metode: 3 M60 Bestemmelsesgrense: 0,01 GC-MULTI

2 Mekoprop-P Dato siste gjennomgang: Kommentarer Både The Pesticide Manual og den svenske databasen vurderer Mekoprop og Mekoprop P til å ha same økotoksikologiske effekt og har derfor same vurderingen av begg to. Kjemisk konfigurasjonsformel se Mekoprop.Den store forskjellen mellom Mekoprop og Mekoprop-P er at Mekoprop er vurdert opp mot vannplanter, mens den Tyske basen ikke har med denne kategorien.

3 Vedlegg for Mekoprop Kilde: Svensk undersøkelse Mecoprop, mecoprop-p Mecoprop is an auxin type systemic herbicide, intended for weed control in cereals and pastures. Mecoprop and mecoprop-p are under evaluation within the framework of EU Dir. 91/414. Cl OCHCO 2 H Cl O C CO2 H Mecoprop H Mecoprop-p 1.1 Physico-chemical properties Physico-chemical properties of mecoprop and mecoprop-p are summarised in table 1.1. Table 1.1: Physico-chemical properties of mecoprop and mecoprop-p. Mecoprop Mecoprop-p Reference CAS-No , 2 Empirical formula C 10 H 11 ClO 3 C 10 H 11 ClO 3 1, 2 Molecular weight [g/mol] , 2 Solubility in water [mg/kg] 734 at 25 C 860 at 20 C 1, 2 pka at 20 C 4 Vapour pressure [Pa] 0.12 at 22.5 C at 20 C 1, 2 Log P ow 1.18 at 23 C 1.43 at ph 5, 20 C 0.02 at ph 5, 20 C 1, 2 Henry s law constant [Pa m 3 /mol] at ph 5, 20 C at 25 C at 20 C 1, Toxicity to aquatic organisms The toxicity of mecoprop and mecoprop-p to aquatic organisms is summarised in table 1.2. Table 1.2: Aquatic ecotoxicity data of mecoprop and mecoprop-p. Species End-point Exposure duration Result [mg as/l] Reference Algae Pseudokirchneriella Subcapitata 70 h, static -P EC NOEC 27 Anabaena flos-aquae growth rate 72 h E r C NOEC 6.0 Higher aquatic plant Lemna minor frond numbers 14 d EC ) Crustaceans LOEC

4 Daphnia magna 48 h, static EC 50 >100 3 Daphnia magna 48 h, static EC 50 >100 1 Daphnia magna 48 h, static EC 50 >91 1 Daphnia magna reproduction 21 d, semi-static NOEC P Daphnia magna reproduction 28 d, semi-static NOEC ) 1 Fish Oncorynchus mykiss mortality 96 h, static LC Lepomis mortality 96 h, static LC 50 >69 1,2) 3 macrochirus Oncorynchus mykiss mortality 96 h, static LC ,2) 3 Oncorynchus mykiss mortality 96 h, flow through LC ) 1 Cyprinus carpio mortality 96 h, static LC ) 1 Oncorynchus mykiss mortality 96 h, static LC Oncorynchus mykiss mortality 96 h, static LC P Lepomis mortality 96 h, static LC macrochirus Oncorynchus mykiss 21 d, flow through NOEC >89 1) 1 Oncorynchus mykiss sub lethal 28 d, flow through -P NOEC ) Test performed on salt compound. Value expressed as active substance. 2) Test performed on substance with purity <90%. Value expressed as active substance. 3) Effect concentration basis for calculation of PNEC. Test substance purity 68.4% The most sensitive (acute effects) group of species were Lemna minor, with an EC 50 of 1.6 mg/l and NOEC of 0.4 mg/l. Since the acute/chronic ratio is low and does not guarantee appropriate protection against acute effects, the PNEC is based on acute toxicity data. Hence, the lowest EC 50 of 1.6 mg/l is divided by a factor of 100, which results in a PNEC of mg/l. 1.3 Bioaccumulation and persistence Mecoprop and mecoprop-p are expected to have a low bioaccumulation potential. The degradation time is approximately 20 days in water (laboratory conditions, 20 C). In water/sediment systems the main portion of mecoprop and mecoprop-p is located in the water phase (1,2). 1.4 Proposed water quality objective Since PNEC is mg/l, the proposed water quality objective for mecoprop and mecoprop-p is 0.02 mg/l.

5 1.5 Comments Mecoprop-p does not show more or higher ecotoxicological effects than racemic mecoprop. Degradation route and major metabolites are unknown. Mecoprop and mecoprop-p may reach surface- and ground waters through the soil profile (1,2). 1.6 Literature (1) European Commission Peer Review Programme. Mecoprop Monograph, (2) European Commission Peer Review Programme. Mecorop-P Monograph, (3) Pesticide Ecotoxicity Database, Environmental Fate and Effects Division of the Office of Pesticide Programs, U.S. EPA. Washington DC. (4) Tomlin, C., The Pesticide Manual, 12 th edition. British Crop Protection Council. (5) European Commission Peer Review Programme. Mecoprop-p Review report, 2003,