(12) Translation of european patent specification

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1 (12) Translation of european patent specification (11) NO/EP B1 (19) NO NORWAY (1) Int Cl. C07D 209/08 ( ) A61K 31/63 ( ) A61P 3/00 ( ) C07D 213/71 ( ) C07D 231/6 ( ) C07D 23/04 ( ) C07D 26/02 ( ) C07D 28/14 ( ) C07D 29/1 ( ) C07D 311/14 ( ) Norwegian Industrial Property Office (21) Translation Published (80) Date of The European Patent Office Publication of the Granted Patent (86) European Application Nr (86) European Filing Date (87) The European Application s Publication Date (30) Priority , US, P (84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA RS (73) Proprietor AbbVie Inc., 1 North Waukegan Road, North Chicago, IL 60064, US-USA (72) Inventor Hexamer, Laura, 439 Gatewood Lane, Grayslake, IL Illinois 60030, US-USA Ding, Hong, 746 Glem Drive, Gurnee, IL Illinois 60031, US-USA Elmore, Steven, W., 239 Ash Lane, Northbrook, IL Illinois 60062, US-USA Kunzer, Aaron, R., 61 W. Burr Oak Drive, Arlington Heights, IL Illinois 60004, US- USA Song, Xiaohong, Sulkey Drive, Grayslake, IL Illinois 60030, US-USA Souers, Andrew, J., 901 Hinmam Apt. 3a, Evanston, IL Illinois 60202, US-USA Sullivan, Gerard, M., 1212 Tulip Tree Court, Lake Villa, IL Illinois 60046, US-USA Tao, Zhi-fu, 132 Vineyard Drive, Gurnee, IL Illinois 60031, US-USA Wendt, Michael, D., 144 Maidstone Drive, Vernon Hills, IL Illinois 60061, US-USA (74) Agent or Attorney Oslo Patentkontor AS, Postboks 7007 Majorstua, 0306 OSLO, Norge (4) Title Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases (6) References Cited: WO-A2-2010/06824 WO-A2-2010/0686 WO-A2-2010/ US-A

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3 Enclosed is a translation of the patent claims in Norwegian. Please note that as per the Norwegian Patents Acts, section 66i the patent will receive protection in Norway only as far as there is agreement between the translation and the language of the application/patent granted at the EPO. In matters concerning the validity of the patent, language of the application/patent granted at the EPO will be used as the basis for the decision. The patent documents published by the EPO are available through Espacenet (http://worldwide.espacenet.com) or via the search engine on our website here: https://search.patentstyret.no/ NO/EP211264

4 1 Patentkrav 1. Forbindelse, eller et terapeutisk akseptabelt salt derav, hvor forbindelsen er valgt fra gruppen omfattende: - Gruppe 1: 4-[4-(3,3-difenylprop-2-enyl)piperazin-1-yl]-N-[(3-nitrofenyl)sulfonyl] piperazin-1-yl) piperazin-1-yl) 10 piperazin-1-yl) 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-(fenylsulfonyl) 1 nitrofenyl)sulfonyl] 2-(2-fenyletoksy) 20 fenoksy N-[(2-bromfenyl)sulfonyl]-4-(4-{[2-(4-klorfenyl)cykloheks-1-en-1-yl]metyl}- N-[(3-bromfenyl)sulfonyl]-4-(4-{[2-(4-klorfenyl)cykloheks-1-en-1-yl]metyl}- N-[(4-bromfenyl)sulfonyl]-4-(4-{[2-(4-klorfenyl)cykloheks-1-en-1-yl]metyl}- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-nitrofenyl)sulfonyl]- 2-(benzyloksy)-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-n-[(3-nitrofenyl)sulfonyl]- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl-2-fenoksy-n-(fenylsulfonyl)- N-[(4-bromfenyl)sulfonyl]-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-

5 2 4-[4-(1,1 -bifenyl-4-ylmetyl)-3-isopropylpiperazin-1-yl]-n-(fenylsulfonyl) (fenyltio) nitrofenyl)sulfonyl] sulfonyl] 10 sulfonyl] (2-fenyletyl) 1 (fenylsulfinyl) 20 fenoksy fenoksy 2 2-(benzylamino)-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-2-benzyl-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-nitrofenyl)- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(4-nitrofenyl)sulfonyl]- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(4-hydroksyfenyl)- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(4-fluorfenyl)sulfonyl]- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-fluorfenyl)sulfonyl]- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(4-nitrofenyl)sulfonyl]-2-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-fluorfenyl)sulfonyl]-2-4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(4-fluorfenyl)sulfonyl]-2- fenoksy

6 3 sulfonyl] (fenylsulfonyl) sulfonyl]-2-fenoksy 2-(1H-indol-4-yloksy)-N-[(3-nitrofenyl)sulfonyl] og 10 2-(1H-indol-4-yloksy)-N-(fenylsulfonyl) og - Gruppe 2: (1H-indol--yloksy)-N-[(3-nitrofenyl)sulfonyl] 1 (1H-indol--yloksy)-N-(fenylsulfonyl) [(3-cyanofenyl)sulfonyl]-2-(1H-indol--yloksy) 20 [(3-klorfenyl)sulfonyl]-2-(1H-indol--yloksy) [(3-fluorfenyl)sulfonyl]-2-(1H-indol--yloksy) 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-2-metoksy-n-[(3-nitrofenyl)- 4-{4-[(4 -klor-1,1 -bifenyl-2-yl)metyl]piperazin-1-yl}-n-[(4-klor-3-nitrofenyl)- 4-[4-({4 -klor-3-[2-(dimetylamino)etoksy]-1,1 -bifenyl-2-yl}metyl)piperazin-1-yl]- 4-[4-({4 -klor-3-[2-(dimetylamino)etoksy]-1,1 -bifenyl-2-yl}metyl)piperazin-1-yl]- 4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-2-4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-2-4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-N- 4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-N- 4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-N- 4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-2- (1H-indol--yloksy)-N-(2-naftylsulfonyl)

7 4 (1H-indol--yloksy)-N-(isokinolin--ylsulfonyl) benzoksazin-6-yl)sulfonyl] benzotiadiazin-7-yl)sulfonyl] 10 1-naftyl}sulfonyl) tetrahydronaftalen-2-yl)sulfonyl] og 4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-2-4-{4-[(4 -klorbifenyl-2-yl)metyl]piperazin-1-yl}-n-[(2-klorpyridin-3-yl)sulfonyl]- 4-{4-[(4 -klorbifenyl-2-yl)metyl]piperazin-1-yl}-n-[(3-okso-3,4-dihydro-2h-1,4-4-{4-[(4 -klorbifenyl-2-yl)metyl]piperazin-1-yl}-n-[(6-klor-1,1-dioksido-2h-1,2,4-4-{4-[(4 -klorbifenyl-2-yl)metyl]piperazin-1-yl}-n-({-[etyl(trifluoracetyl)amino]- 4-{4-[(4 -klorbifenyl-2-yl)metyl]piperazin-1-yl}-n-[(,,8,8-tetrametyl-,6,7,8-4-{4-[(4 -klorbifenyl-2-yl)metyl]piperazin-1-yl}-n-[(2-okso-2h-kromen-6-yl)- sulfonyl]benzamid Forbindelse eller terapeutisk akseptabelt salt ifølge krav 1, hvor forbindelsen er 4-(4-{[2-(4-klorfenyl)-4,4-dimetylcykloheks-1-en-1-yl]metyl}piperazin-1-yl)-2- (1H-indol--yloksy)-N-[(3-nitrofenyl)sulfonyl]benzamid Sammensetning for behandling av blærekreft, hjernekreft, brystkreft, benmargskreft, livmorhalskreft, kronisk lymfatisk leukemi, kolorektal kreft, øsofageal kreft, hepatocellulær kreft, lymfoblastisk leukemi, follikulært lymfom, en lymfoid ondartethet av T-celle- eller B-celle-opphav, melanom, myelogen leukemi, myeloma, kreft i munnhulen, eggstokkreft, ikke-småcellet lungekreft, prostatakreft, småcellet lungekreft eller miltkreft, hvilken sammensetning omfatter en eksipiens og en terapeutisk virksom mengde av en forbindelse eller et terapeutisk akseptabelt salt ifølge krav 1 eller Forbindelse eller terapeutisk akseptabelt salt ifølge krav 1 eller 2 for anvendelse ved behandling av blærekreft, hjernekreft, brystkreft, benmargskreft, livmorhalskreft, kronisk lymfatisk leukemi, kolorektal kreft, øsofageal kreft, hepatocellulær kreft, lymfoblastisk leukemi, follikulært lymfom, en lymfoid

8 ondartethet av T-celle- eller B-celle-opphav, melanom, myelogen leukemi, myeloma, kreft i munnhulen, eggstokkreft, ikke-småcellet lungekreft, prostatakreft, småcellet lungekreft eller miltkreft i en pasient.

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(12) Translation of european patent specification

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